PURPOSE: Hepatic or pulmonary resections for colorectal metastases are regarded as standard treatment worldwide; however, the clinical significance of both hepatic and pulmonary resections for colorectal metastases remains undefined. We reviewed our clinical experience to evaluate the benefit of this treatment. METHODS: Between 1986 and 2010, 186 patients underwent potentially curative hepatic and/or pulmonary resections for colorectal metastases. Of these patients, 25 underwent both treatments (Group C), 100 underwent hepatic resections alone (Group H), and 61 underwent pulmonary resections alone (Group L). Univariate and multivariate analyses of the clinical and pathological variables in Group C and comparative survival analyses between Group C and Groups H-L were performed. RESULTS: In Group C, the median survival after primary tumor resection, initial metastasectomy, and last metastasectomy were 97, 60, and 35 months, respectively, and the 5-year overall survival rates were 63, 54, and 38%, respectively. Multivariate analyses after initial metastasectomy revealed rectal tumors, multiple hepatic tumors, and simultaneous metastases as poor prognostic factors. Comparative survival analyses revealed no significant difference in overall survival between Group C and Groups H-L. CONCLUSION: Hepatic and pulmonary resections for colorectal metastases improve survival and may even offer the potential for cure in selected patients.
PURPOSE: Hepatic or pulmonary resections for colorectal metastases are regarded as standard treatment worldwide; however, the clinical significance of both hepatic and pulmonary resections for colorectal metastases remains undefined. We reviewed our clinical experience to evaluate the benefit of this treatment. METHODS: Between 1986 and 2010, 186 patients underwent potentially curative hepatic and/or pulmonary resections for colorectal metastases. Of these patients, 25 underwent both treatments (Group C), 100 underwent hepatic resections alone (Group H), and 61 underwent pulmonary resections alone (Group L). Univariate and multivariate analyses of the clinical and pathological variables in Group C and comparative survival analyses between Group C and Groups H-L were performed. RESULTS: In Group C, the median survival after primary tumor resection, initial metastasectomy, and last metastasectomy were 97, 60, and 35 months, respectively, and the 5-year overall survival rates were 63, 54, and 38%, respectively. Multivariate analyses after initial metastasectomy revealed rectal tumors, multiple hepatic tumors, and simultaneous metastases as poor prognostic factors. Comparative survival analyses revealed no significant difference in overall survival between Group C and Groups H-L. CONCLUSION: Hepatic and pulmonary resections for colorectal metastases improve survival and may even offer the potential for cure in selected patients.
Authors: Leonard B Saltz; Stephen Clarke; Eduardo Díaz-Rubio; Werner Scheithauer; Arie Figer; Ralph Wong; Sheryl Koski; Mikhail Lichinitser; Tsai-Shen Yang; Fernando Rivera; Felix Couture; Florin Sirzén; Jim Cassidy Journal: J Clin Oncol Date: 2008-04-20 Impact factor: 44.544
Authors: J F Regnard; D Grunenwald; L Spaggiari; P Girard; D Elias; M Ducreux; P Baldeyrou; P Levasseur Journal: Ann Thorac Surg Date: 1998-07 Impact factor: 4.330
Authors: P Girard; M Ducreux; P Baldeyrou; P Rougier; T Le Chevalier; J Bougaran; P Lasser; B Gayet; P Ruffié; D Grunenwald Journal: J Clin Oncol Date: 1996-07 Impact factor: 44.544
Authors: Alan I Valderrama-Treviño; Baltazar Barrera-Mera; Jesús C Ceballos-Villalva; Eduardo E Montalvo-Javé Journal: Euroasian J Hepatogastroenterol Date: 2017-09-29
Authors: Jon Zabaleta; Borja Aguinagalde; Iker Lopez; Arantza Fernandez-Monge; Jose M Izquierdo; Jose I Emparanza Journal: Cancer Biol Med Date: 2017-08 Impact factor: 4.248
Authors: Philip Sutera; Ronny Kalash; David A Clump; David D'Ambrosio; Alina Mihai; Steven A Burton; Dwight E Heron Journal: Adv Radiat Oncol Date: 2018-09-14