Association of CD14 gene -159C/T polymorphism with allergic rhinitis risk: a meta-analysis.

The -159C/T polymorphism in the CD14 gene has been implicated in susceptibility to allergic rhinitis (AR), but results were conflicting. The aim of this study is to investigate the association between the CD14-159C/T polymorphism and the risk of AR. All eligible case-control studies published up to July 2013 were identified by searching PubMed, Web of Science and CNKI. Pooled odds ratio with 95% confidence interval (95% CI) was used to access the strength of this association in fixed- or random-effects model. A total of seven case-control studies, including 887 cases and 889 controls, were selected. Overall, no significant association between the CD14-159C/T polymorphism and AR risk was found. Besides, stratified analysis with ethnicity and source of control also indicated that no significant association between CD14-159C/T and the risk of AR under all for genetic model was observed. This meta-analysis indicated that the CD14-159C/T polymorphism is not associated with AR risk.