Literature DB >> 24170072

Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine.

Corey J Bishop1, Jayoung Kim, Jordan J Green.   

Abstract

To realize the potential of regenerative medicine, controlling the delivery of biomolecules in the cellular microenvironment is important as these factors control cell fate. Controlled delivery for tissue engineering and regenerative medicine often requires bioengineered materials and cells capable of spatiotemporal modulation of biomolecule release and presentation. This review discusses biomolecule delivery from the outside of the cell inwards through the delivery of soluble and insoluble biomolecules as well as from the inside of the cell outwards through gene transfer. Ex vivo and in vivo therapeutic strategies are discussed, as well as combination delivery of biomolecules, scaffolds, and cells. Various applications in regenerative medicine are highlighted including bone tissue engineering and wound healing.

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Year:  2013        PMID： 24170072      PMCID： PMC4006325          DOI： 10.1007/s10439-013-0932-1

Source DB:  PubMed          Journal:  Ann Biomed Eng        ISSN： 0090-6964            Impact factor:   3.934


  86 in total

1.  Runx2 overexpression in bone marrow stromal cells accelerates bone formation in critical-sized femoral defects.

Authors:  Abigail M Wojtowicz; Kellie L Templeman; Dietmar W Hutmacher; Robert E Guldberg; Andrés J García
Journal:  Tissue Eng Part A       Date:  2010-09       Impact factor: 3.845

2.  Effect of scaffold architecture and BMP-2/BMP-7 delivery on in vitro bone regeneration.

Authors:  Pinar Yilgor; Rui A Sousa; Rui L Reis; Nesrin Hasirci; Vasif Hasirci
Journal:  J Mater Sci Mater Med       Date:  2010-08-26       Impact factor: 3.896

3.  Spatial control of gene expression within a scaffold by localized inducer release.

Authors:  Priya R Baraniak; Devin M Nelson; Cory E Leeson; Anand K Katakam; Jennifer L Friz; Dean E Cress; Yi Hong; Jianjun Guan; William R Wagner
Journal:  Biomaterials       Date:  2011-01-26       Impact factor: 12.479

4.  Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur.

Authors:  Cemal Yazici; Masahiko Takahata; David G Reynolds; Chao Xie; R Jude Samulski; Jade Samulski; E Jeffrey Beecham; Arthur A Gertzman; Mark Spilker; Xinping Zhang; Regis J O'Keefe; Hani A Awad; Edward M Schwarz
Journal:  Mol Ther       Date:  2011-01-04       Impact factor: 11.454

5.  A TALE nuclease architecture for efficient genome editing.

Authors:  Jeffrey C Miller; Siyuan Tan; Guijuan Qiao; Kyle A Barlow; Jianbin Wang; Danny F Xia; Xiangdong Meng; David E Paschon; Elo Leung; Sarah J Hinkley; Gladys P Dulay; Kevin L Hua; Irina Ankoudinova; Gregory J Cost; Fyodor D Urnov; H Steve Zhang; Michael C Holmes; Lei Zhang; Philip D Gregory; Edward J Rebar
Journal:  Nat Biotechnol       Date:  2010-12-22       Impact factor: 54.908

6.  Nanoparticle based delivery of hypoxia-regulated VEGF transgene system combined with myoblast engraftment for myocardial repair.

Authors:  Lei Ye; Wei Zhang; Li-Ping Su; Husnain K Haider; Kian-Keong Poh; Mary J Galupo; Geronica Songco; Ruo-Wen Ge; Huay-Cheem Tan; Eugene K W Sim
Journal:  Biomaterials       Date:  2011-01-08       Impact factor: 12.479

7.  Targeted gene-and-host progenitor cell therapy for nonunion bone fracture repair.

Authors:  Nadav Kimelman-Bleich; Gadi Pelled; Yoram Zilberman; Ilan Kallai; Olga Mizrahi; Wafa Tawackoli; Zulma Gazit; Dan Gazit
Journal:  Mol Ther       Date:  2010-09-21       Impact factor: 11.454

Review 8.  Multi-stage delivery nano-particle systems for therapeutic applications.

Authors:  Rita E Serda; Biana Godin; Elvin Blanco; Ciro Chiappini; Mauro Ferrari
Journal:  Biochim Biophys Acta       Date:  2010-05-21

Review 9.  Ex vivo gene transfer and correction for cell-based therapies.

Authors:  Luigi Naldini
Journal:  Nat Rev Genet       Date:  2011-03-29       Impact factor: 53.242

10.  In vivo genome editing restores haemostasis in a mouse model of haemophilia.

Authors:  Hojun Li; Virginia Haurigot; Yannick Doyon; Tianjian Li; Sunnie Y Wong; Anand S Bhagwat; Nirav Malani; Xavier M Anguela; Rajiv Sharma; Lacramiora Ivanciu; Samuel L Murphy; Jonathan D Finn; Fayaz R Khazi; Shangzhen Zhou; David E Paschon; Edward J Rebar; Frederic D Bushman; Philip D Gregory; Michael C Holmes; Katherine A High
Journal:  Nature       Date:  2011-06-26       Impact factor: 49.962
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  6 in total

1.  Layer-by-layer inorganic/polymeric nanoparticles for kinetically controlled multigene delivery.

Authors:  Corey J Bishop; Allen L Liu; David S Lee; Richard J Murdock; Jordan J Green
Journal:  J Biomed Mater Res A       Date:  2015-11-18       Impact factor: 4.396

Review 2.  Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles.

Authors:  Corey J Bishop; Kristen L Kozielski; Jordan J Green
Journal:  J Control Release       Date:  2015-10-01       Impact factor: 9.776

3.  Quantification of cellular and nuclear uptake rates of polymeric gene delivery nanoparticles and DNA plasmids via flow cytometry.

Authors:  Corey J Bishop; Rebecca L Majewski; Toni-Rose M Guiriba; David R Wilson; Nupura S Bhise; Alfredo Quiñones-Hinojosa; Jordan J Green
Journal:  Acta Biomater       Date:  2016-03-24       Impact factor: 8.947

Review 4.  A Closer Look at Schlemm's Canal Cell Physiology: Implications for Biomimetics.

Authors:  Cula N Dautriche; Yangzi Tian; Yubing Xie; Susan T Sharfstein
Journal:  J Funct Biomater       Date:  2015-09-21

Review 5.  Novel applications of platelet concentrates in tissue regeneration (Review).

Authors:  Zhen-Yu Ding; Ying Tan; Qian Peng; Jun Zuo; Ning Li
Journal:  Exp Ther Med       Date:  2021-01-18       Impact factor: 2.447

6.  In Vitro Evaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Wounds.

Authors:  Elizabeth A Wahl; Fernando A Fierro; Thomas R Peavy; Ursula Hopfner; Julian F Dye; Hans-Günther Machens; José T Egaña; Thilo L Schenck
Journal:  Biomed Res Int       Date:  2015-10-04       Impact factor: 3.411
  6 in total

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