Youn Yi Jo1, Yong Seon Choi2, Dong Jin Joo3, Young-Chul Yoo2, Seung Gyun Nam2, Shin Ok Koh4. 1. Department of Anesthesiology and Pain Medicine, Gachon University Gil Medical Center, Incheon, South Korea. 2. Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea. 3. Department of Surgery and The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea. 4. Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: sokoh@yuhs.ac.
Abstract
BACKGROUND: Although there were some reports predicting postoperative morbidity and mortality in patients undergoing liver transplantation, most of them studied deceased-donor liver transplantation (DDLT). In this context, we performed this study to predict early mortality after liver transplantation from preoperative variables in both living-donor liver transplantation (LDLT) and DDLT. METHODS: We retrospectively reviewed the medical charts of 159 patients undergoing liver transplantation (LDLT, n = 103; DDLT, n = 56). Then, we identified the factors that independently predicted 30-day mortality using multivariable logistic regression models. RESULTS: The 30-day mortality and 1-year mortality for DDLT versus LDLT were 30% versus 6% and 39% versus 11%, respectively. In multivariate logistic regression analysis, pretransplant hepatic encephalopathy (odds ratio, 5.594; 95% confidence interval, 1.110-28.194; p = 0.037) in patients with DDLT and serum creatinine (odds ratio, 4.883; 95% confidence interval, 1.296-18.399; p = 0.019) in patients with LDLT were the independent risk factors for a composite of 30-day mortality. CONCLUSION: In conclusion, hepatic encephalopathy in DDLT and serum creatinine level in LDLT were the significant pretransplant variables that were related with early death after LT.
BACKGROUND: Although there were some reports predicting postoperative morbidity and mortality in patients undergoing liver transplantation, most of them studied deceased-donor liver transplantation (DDLT). In this context, we performed this study to predict early mortality after liver transplantation from preoperative variables in both living-donor liver transplantation (LDLT) and DDLT. METHODS: We retrospectively reviewed the medical charts of 159 patients undergoing liver transplantation (LDLT, n = 103; DDLT, n = 56). Then, we identified the factors that independently predicted 30-day mortality using multivariable logistic regression models. RESULTS: The 30-day mortality and 1-year mortality for DDLT versus LDLT were 30% versus 6% and 39% versus 11%, respectively. In multivariate logistic regression analysis, pretransplant hepatic encephalopathy (odds ratio, 5.594; 95% confidence interval, 1.110-28.194; p = 0.037) in patients with DDLT and serum creatinine (odds ratio, 4.883; 95% confidence interval, 1.296-18.399; p = 0.019) in patients with LDLT were the independent risk factors for a composite of 30-day mortality. CONCLUSION: In conclusion, hepatic encephalopathy in DDLT and serum creatinine level in LDLT were the significant pretransplant variables that were related with early death after LT.
Authors: Mohammed A Nafea; Ayman Alsebaey; Ahmed Abd El Aal Sultan; Mohammed Hisham Goda; Ahmed Salman; Hanaa Said Rashed; Ahmed Soliman; Mai Elshenoufy; Mostafa Abdelrahman Journal: Ann Saudi Med Date: 2019-10-03 Impact factor: 1.526