OBJECTIVE: The etiology of childhood cancers is largely unknown. Studies have suggested that birth characteristics may be associated with risk. Our goal was to evaluate the risk of childhood cancers in relation to fetal growth. METHODS: We conducted a case-control study nested within Nordic birth registries. The study included cancer cases diagnosed in Denmark, Finland, Norway, and Sweden among children born from 1967 to 2010 and up to 10 matched controls per case, totaling 17,698 cases and 172,422 controls. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were derived from conditional logistic regression. RESULTS: Risks of all childhood cancers increased with increasing birth weight (P trend ≤ .001). Risks of acute lymphoid leukemia and Wilms tumor were elevated when birth weight was >4000 g and of central nervous system tumors when birth weight was >4500 g. Newborns large for gestational age were at increased risk of Wilms tumor (OR: 2.1 [95% CI: 1.2-3.6]) and connective/soft tissue tumors (OR: 2.1 [95% CI: 1.1-4.4]). In contrast, the risk of acute myeloid leukemia was increased among children born small for gestational age (OR: 1.8 [95% CI: 1.1-3.1]). Children diagnosed with central nervous system tumors at <1 year of age had elevated risk with increasing head circumference (P trend < .001). Those with head circumference >39 cm had the highest risk (OR: 4.7 [95% CI: 2.5-8.7]). CONCLUSIONS: In this large, Nordic population-based study, increased risks for several childhood tumors were associated with measures of fetal growth, supporting the hypothesis that tumorigenesis manifesting in childhood is initiated in utero.
OBJECTIVE: The etiology of childhood cancers is largely unknown. Studies have suggested that birth characteristics may be associated with risk. Our goal was to evaluate the risk of childhood cancers in relation to fetal growth. METHODS: We conducted a case-control study nested within Nordic birth registries. The study included cancer cases diagnosed in Denmark, Finland, Norway, and Sweden among children born from 1967 to 2010 and up to 10 matched controls per case, totaling 17,698 cases and 172,422 controls. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were derived from conditional logistic regression. RESULTS: Risks of all childhood cancers increased with increasing birth weight (P trend ≤ .001). Risks of acute lymphoid leukemia and Wilms tumor were elevated when birth weight was >4000 g and of central nervous system tumors when birth weight was >4500 g. Newborns large for gestational age were at increased risk of Wilms tumor (OR: 2.1 [95% CI: 1.2-3.6]) and connective/soft tissue tumors (OR: 2.1 [95% CI: 1.1-4.4]). In contrast, the risk of acute myeloid leukemia was increased among children born small for gestational age (OR: 1.8 [95% CI: 1.1-3.1]). Children diagnosed with central nervous system tumors at <1 year of age had elevated risk with increasing head circumference (P trend < .001). Those with head circumference >39 cm had the highest risk (OR: 4.7 [95% CI: 2.5-8.7]). CONCLUSIONS: In this large, Nordic population-based study, increased risks for several childhood tumors were associated with measures of fetal growth, supporting the hypothesis that tumorigenesis manifesting in childhood is initiated in utero.
Authors: C Papadopoulou; C N Antonopoulos; T N Sergentanis; P Panagopoulou; M Belechri; E T Petridou Journal: Int J Cancer Date: 2011-04-20 Impact factor: 7.396
Authors: Kate A O'Neill; Kathryn J Bunch; Tim J Vincent; Logan G Spector; Anthony V Moorman; Michael F G Murphy Journal: Pediatr Blood Cancer Date: 2011-06-16 Impact factor: 3.167
Authors: Shaina L Stacy; Jeanine M Buchanich; Zhen-Qiang Ma; Christina Mair; Linda Robertson; Ravi K Sharma; Evelyn O Talbott; Jian-Min Yuan Journal: Am J Epidemiol Date: 2019-08-01 Impact factor: 4.897
Authors: Lindsay A Williams; Michaela Richardson; Erin L Marcotte; Jenny N Poynter; Logan G Spector Journal: Pediatr Blood Cancer Date: 2019-02-28 Impact factor: 3.167
Authors: Julia E Heck; Xiwen Huang; Kara L Calkins; Yuelian Sun; Jorn Olsen; Beate Ritz; Johnni Hansen Journal: Int J Cancer Date: 2019-11-04 Impact factor: 7.396
Authors: Anne Gulbech Ording; Lotte Brix Christensen; Tone Bjørge; David R Doody; Anders Ekbom; Ingrid Glimelius; Tom Grotmol; Gunnar Larfors; Beth A Mueller; Karin E Smedby; Steinar Tretli; Rebecca Troisi; Henrik Toft Sørensen Journal: Acta Oncol Date: 2020-03-14 Impact factor: 4.089
Authors: Julia E Heck; Di He; Carla Janzen; Noah Federman; Jorn Olsen; Beate Ritz; Johnni Hansen Journal: Pediatr Blood Cancer Date: 2018-09-25 Impact factor: 3.167
Authors: Jessica R B Musselman; Logan G Spector; Mark D Krailo; Gregory H Reaman; Amy M Linabery; Jenny N Poynter; Susan K Stork; Peter C Adamson; Julie A Ross Journal: Cancer Date: 2014-05-29 Impact factor: 6.860