BACKGROUND: The purpose of this study was to determine factors that impact recurrence and long-term survival of head and neck adenoid cystic carcinoma (ACC). METHODS: We conducted a retrospective review of 87 patients with head and neck ACC who were evaluated between 1992 and 2009. Staining for Ki-67, p53, α-estrogen receptor (αER), and progesterone receptor (PR) was performed. RESULTS: Forty men (46%) and 47 women (54%) were included in this study. Median follow-up for patients was 98 months. Five-year recurrence-free and overall survival (OS) rates were 56% and 81%, respectively. Ki-67 and p53 expression was observed in 5 (6%) and 2 (2%) patients, respectively. αER and PR were all negative. The most important determinants of disease-free survival (DFS) were perineural invasion (PNI; p = .001) and female sex (p = .027). Disease site (major vs minor salivary gland) was the only predictor of worse OS on multivariate analysis. CONCLUSION: Perineural invasion, female sex, and disease site were the most consistent predictors of poor outcome in head and neck ACC.
BACKGROUND: The purpose of this study was to determine factors that impact recurrence and long-term survival of head and neck adenoid cystic carcinoma (ACC). METHODS: We conducted a retrospective review of 87 patients with head and neck ACC who were evaluated between 1992 and 2009. Staining for Ki-67, p53, α-estrogen receptor (αER), and progesterone receptor (PR) was performed. RESULTS: Forty men (46%) and 47 women (54%) were included in this study. Median follow-up for patients was 98 months. Five-year recurrence-free and overall survival (OS) rates were 56% and 81%, respectively. Ki-67 and p53 expression was observed in 5 (6%) and 2 (2%) patients, respectively. αER and PR were all negative. The most important determinants of disease-free survival (DFS) were perineural invasion (PNI; p = .001) and female sex (p = .027). Disease site (major vs minor salivary gland) was the only predictor of worse OS on multivariate analysis. CONCLUSION: Perineural invasion, female sex, and disease site were the most consistent predictors of poor outcome in head and neck ACC.
Authors: E P Prokopakis; C H Snyderman; E Y Hanna; R L Carrau; J T Johnson; F D'Amico Journal: Am J Otolaryngol Date: 1999 Sep-Oct Impact factor: 1.808
Authors: Eleni M Rettig; Marietta Tan; Shizhang Ling; Raluca Yonescu; Justin A Bishop; Carole Fakhry; Patrick K Ha Journal: Laryngoscope Date: 2015-05-11 Impact factor: 3.325
Authors: Eleni M Rettig; C Conover Talbot; Mark Sausen; Sian Jones; Justin A Bishop; Laura D Wood; Collin Tokheim; Noushin Niknafs; Rachel Karchin; Elana J Fertig; Sarah J Wheelan; Luigi Marchionni; Michael Considine; Shizhang Ling; Carole Fakhry; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Patrick K Ha; Nishant Agrawal Journal: Cancer Prev Res (Phila) Date: 2016-02-09