Literature DB >> 24166757

Characterization of N-demethyllincosamide methyltransferases LmbJ and CcbJ.

Lucie Najmanová1, Eva Kutejová, Jan Kadlec, Marek Polan, Jana Olšovská, Oldřich Benada, Jitka Novotná, Zdeněk Kameník, Petr Halada, Jacob Bauer, Jiří Janata.   

Abstract

Chemical diversity: Two SAM-dependent N-methyltransferases-LmbJ from the biosynthesis of the antibiotic lincomycin and CcbJ from celesticetin biosynthesis-have been characterized and compared. Both tested enzymes form multimers and are able to utilize N-demethyllincomycin, the natural substrate of LmbJ, with comparable efficiency.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  N-methyltransferases; Streptomyces; antibiotics; lincomycin; natural products

Mesh：

Substances：

Year:  2013        PMID： 24166757     DOI： 10.1002/cbic.201300389

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  9 in total

1.  Characterization of Enzymes Catalyzing Transformations of Cysteine S-Conjugated Intermediates in the Lincosamide Biosynthetic Pathway.

Authors:  Richiro Ushimaru; Chia-I Lin; Eita Sasaki; Hung-Wen Liu
Journal:  Chembiochem       Date:  2016-07-19       Impact factor: 3.164

2.  Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensis.

Authors:  Yurong Xu; Guoqing Tan; Meilan Ke; Jie Li; Yaqian Tang; Sitong Meng; Jingjing Niu; Yansheng Wang; Ruihua Liu; Hang Wu; Linquan Bai; Lixin Zhang; Buchang Zhang
Journal:  J Ind Microbiol Biotechnol       Date:  2018-03-24       Impact factor: 3.346

3.  Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A.

Authors:  Shao-An Wang; Chia-I Lin; Jiawei Zhang; Richiro Ushimaru; Eita Sasaki; Hung-Wen Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2020-09-21       Impact factor: 11.205

4.  Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism.

Authors:  Jiri Janata; Stanislav Kadlcik; Marketa Koberska; Dana Ulanova; Zdenek Kamenik; Petr Novak; Jan Kopecky; Jitka Novotna; Bojana Radojevic; Kamila Plhackova; Radek Gazak; Lucie Najmanova
Journal:  PLoS One       Date:  2015-03-05       Impact factor: 3.240

5.  Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis.

Authors:  Stanislav Kadlčík; Tomáš Kučera; Dominika Chalupská; Radek Gažák; Markéta Koběrská; Dana Ulanová; Jan Kopecký; Eva Kutejová; Lucie Najmanová; Jiří Janata
Journal:  PLoS One       Date:  2013-12-27       Impact factor: 3.240

6.  Deacetylation of mycothiol-derived 'waste product' triggers the last biosynthetic steps of lincosamide antibiotics.

Authors:  Zdenek Kamenik; Stanislav Kadlcik; Bojana Radojevic; Petra Jiraskova; Marek Kuzma; Radek Gazak; Lucie Najmanova; Jan Kopecky; Jiri Janata
Journal:  Chem Sci       Date:  2015-10-01       Impact factor: 9.825

7.  Elucidation of salicylate attachment in celesticetin biosynthesis opens the door to create a library of more efficient hybrid lincosamide antibiotics.

Authors:  S Kadlcik; Z Kamenik; D Vasek; M Nedved; J Janata
Journal:  Chem Sci       Date:  2017-03-23       Impact factor: 9.825

8.  Comparative transcriptomic analysis reveals the significant pleiotropic regulatory effects of LmbU on lincomycin biosynthesis.

Authors:  Chun-Yan Lin; Ai-Ping Pang; Yue Zhang; Jianjun Qiao; Guang-Rong Zhao
Journal:  Microb Cell Fact       Date:  2020-02-12       Impact factor: 5.328

9.  Multienzyme One-Pot Cascades Incorporating Methyltransferases for the Strategic Diversification of Tetrahydroisoquinoline Alkaloids.

Authors:  Fabiana Subrizi; Yu Wang; Benjamin Thair; Daniel Méndez-Sánchez; Rebecca Roddan; Max Cárdenas-Fernández; Jutta Siegrist; Michael Richter; Jennifer N Andexer; John M Ward; Helen C Hailes
Journal:  Angew Chem Int Ed Engl       Date:  2021-07-16       Impact factor: 16.823
  9 in total

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