Literature DB >> 24165728

No pain, more gain.

James J Cox1, John N Wood.   

Abstract

A new study shows that a specific mutation in SCN11A, which encodes the Nav1.9 voltage-gated sodium channel, underlies a human disorder characterized by insensitivity to pain. This finding provides fresh insights into human pain perception and suggests a new avenue for the development of analgesic drugs.

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Year:  2013        PMID： 24165728     DOI： 10.1038/ng.2810

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  13 in total

1.  A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons.

Authors:  T R Cummins; S D Dib-Hajj; J A Black; A N Akopian; J N Wood; S G Waxman
Journal:  J Neurosci       Date:  1999-12-15       Impact factor: 6.167

Review 2.  Transient receptor potential vanilloid 1 as a therapeutic target in analgesia.

Authors:  János Szolcsányi; Erika Pintér
Journal:  Expert Opin Ther Targets       Date:  2013-02-20       Impact factor: 6.902

3.  A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception.

Authors:  Elisabet Einarsdottir; Anna Carlsson; Jan Minde; Göran Toolanen; Olle Svensson; Göran Solders; Gösta Holmgren; Dan Holmberg; Monica Holmberg
Journal:  Hum Mol Genet       Date:  2004-02-19       Impact factor: 6.150

4.  A de novo gain-of-function mutation in SCN11A causes loss of pain perception.

Authors:  Enrico Leipold; Lutz Liebmann; G Christoph Korenke; Theresa Heinrich; Sebastian Giesselmann; Jonathan Baets; Matthias Ebbinghaus; R Oliver Goral; Tommy Stödberg; J Christopher Hennings; Markus Bergmann; Janine Altmüller; Holger Thiele; Andrea Wetzel; Peter Nürnberg; Vincent Timmerman; Peter De Jonghe; Robert Blum; Hans-Georg Schaible; Joachim Weis; Stefan H Heinemann; Christian A Hübner; Ingo Kurth
Journal:  Nat Genet       Date:  2013-09-15       Impact factor: 38.330

5.  Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314.

Authors:  Michelino Puopolo; Alexander M Binshtok; Gui-Lan Yao; Seog Bae Oh; Clifford J Woolf; Bruce P Bean
Journal:  J Neurophysiol       Date:  2013-01-09       Impact factor: 2.714

6.  NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy.

Authors:  S D Dib-Hajj; L Tyrrell; J A Black; S G Waxman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-21       Impact factor: 11.205

Review 7.  Pain as a channelopathy.

Authors:  Ramin Raouf; Kathryn Quick; John N Wood
Journal:  J Clin Invest       Date:  2010-11-01       Impact factor: 14.808

8.  An SCN9A channelopathy causes congenital inability to experience pain.

Authors:  James J Cox; Frank Reimann; Adeline K Nicholas; Gemma Thornton; Emma Roberts; Kelly Springell; Gulshan Karbani; Hussain Jafri; Jovaria Mannan; Yasmin Raashid; Lihadh Al-Gazali; Henan Hamamy; Enza Maria Valente; Shaun Gorman; Richard Williams; Duncan P McHale; John N Wood; Fiona M Gribble; C Geoffrey Woods
Journal:  Nature       Date:  2006-12-14       Impact factor: 49.962

9.  Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons.

Authors:  Michael S Minett; Mohammed A Nassar; Anna K Clark; Gayle Passmore; Anthony H Dickenson; Fan Wang; Marzia Malcangio; John N Wood
Journal:  Nat Commun       Date:  2012-04-24       Impact factor: 14.919

10.  The Nav1.9 channel regulates colonic motility in mice.

Authors:  Carine Copel; Nadine Clerc; Nancy Osorio; Patrick Delmas; Bruno Mazet
Journal:  Front Neurosci       Date:  2013-04-15       Impact factor: 4.677
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  4 in total

Review 1.  Genetic pain loss disorders.

Authors:  Annette Lischka; Petra Lassuthova; Arman Çakar; Christopher J Record; Jonas Van Lent; Jonathan Baets; Maike F Dohrn; Jan Senderek; Angelika Lampert; David L Bennett; John N Wood; Vincent Timmerman; Thorsten Hornemann; Michaela Auer-Grumbach; Yesim Parman; Christian A Hübner; Miriam Elbracht; Katja Eggermann; C Geoffrey Woods; James J Cox; Mary M Reilly; Ingo Kurth
Journal:  Nat Rev Dis Primers       Date:  2022-06-16       Impact factor: 65.038

2.  Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9.

Authors:  Voraluck Phatarakijnirund; Steven Mumm; William H McAlister; Deborah V Novack; Deborah Wenkert; Karen L Clements; Michael P Whyte
Journal:  Bone       Date:  2015-12-31       Impact factor: 4.398

Review 3.  Pain vulnerability: a neurobiological perspective.

Authors:  Franziska Denk; Stephen B McMahon; Irene Tracey
Journal:  Nat Neurosci       Date:  2014-01-28       Impact factor: 24.884

4.  Editors' Pick: What a pain…, or not!

Authors:  Manfred Kayser
Journal:  Investig Genet       Date:  2014-07-01
  4 in total

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