OBJECTIVE: Describe factors associated with aggressive forms of recurrent respiratory papillomatosis (RRP). MATERIALS AND METHODS: One hundred eighty-nine RRP cases diagnosed between 1985 and 2009 were identified in pathological records. HPV was detected by the SPF-10 method with broad spectrum primers, (version 1). RESULTS: 113 patients had only one surgery (less aggressive) and 76, two or more interventions (more aggressive). The likelihood of aggressive lesions decreased with increasing age at diagnosis and HPV-11 was associated with no significant increase in the risk of aggressiveness. CONCLUSIONS: The age at diagnosis was the main determinant of RRP aggressiveness.
OBJECTIVE: Describe factors associated with aggressive forms of recurrent respiratory papillomatosis (RRP). MATERIALS AND METHODS: One hundred eighty-nine RRP cases diagnosed between 1985 and 2009 were identified in pathological records. HPV was detected by the SPF-10 method with broad spectrum primers, (version 1). RESULTS: 113 patients had only one surgery (less aggressive) and 76, two or more interventions (more aggressive). The likelihood of aggressive lesions decreased with increasing age at diagnosis and HPV-11 was associated with no significant increase in the risk of aggressiveness. CONCLUSIONS: The age at diagnosis was the main determinant of RRP aggressiveness.
Authors: Farrel J Buchinsky; William L Valentino; Nicole Ruszkay; Evan Powell; Craig S Derkay; Riaz Y Seedat; Virgilijus Uloza; Frederik G Dikkers; David E Tunkel; Sukgi S Choi; Anthony J Mortelliti; Paolo Campisi; Juan C Ospina; Adam J Donne; Robert T Sataloff; Stephen F Conley; John E McClay; Ellen M Friedman; Lisa Elden; Dale A Tylor; Clark A Rosen; Libby J Smith; Graeme J Copley; David E Karas; John M Schweinfurth; Charles M Myer; Brian J Wiatrak; Joseph E Dohar; Steven E Sobol; Robert W Bastian; Richard J H Smith; Marshall E Smith; Abebe M Wassie; James C Post; Garth D Ehrlich Journal: PLoS One Date: 2019-06-13 Impact factor: 3.240