Literature DB >> 24165680

mTOR complexes in neurodevelopmental and neuropsychiatric disorders.

Mauro Costa-Mattioli1, Lisa M Monteggia.   

Abstract

The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.

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Year:  2013        PMID： 24165680     DOI： 10.1038/nn.3546

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  100 in total

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Authors:  E Fombonne
Journal:  Psychol Med       Date:  1999-07       Impact factor: 7.723

2.  mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons.

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Journal:  Neuron       Date:  2013-02-20       Impact factor: 17.173

Review 3.  The functions and regulation of the PTEN tumour suppressor.

Authors:  Min Sup Song; Leonardo Salmena; Pier Paolo Pandolfi
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4.  Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

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Journal:  J Biol Chem       Date:  2010-04-28       Impact factor: 5.157

5.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

Authors:  J Heitman; N R Movva; M N Hall
Journal:  Science       Date:  1991-08-23       Impact factor: 47.728

6.  Acute suppression of spontaneous neurotransmission drives synaptic potentiation.

Authors:  Elena Nosyreva; Kristen Szabla; Anita E Autry; Alexey G Ryazanov; Lisa M Monteggia; Ege T Kavalali
Journal:  J Neurosci       Date:  2013-04-17       Impact factor: 6.167

7.  Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.

Authors:  Lynsey Meikle; Kristen Pollizzi; Anna Egnor; Ioannis Kramvis; Heidi Lane; Mustafa Sahin; David J Kwiatkowski
Journal:  J Neurosci       Date:  2008-05-21       Impact factor: 6.167

8.  P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.

Authors:  Ivette Hernández-Negrete; Jorge Carretero-Ortega; Hans Rosenfeldt; Ricardo Hernández-García; J Victor Calderón-Salinas; Guadalupe Reyes-Cruz; J Silvio Gutkind; José Vázquez-Prado
Journal:  J Biol Chem       Date:  2007-06-12       Impact factor: 5.157

Review 9.  Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies.

Authors:  Michael Wong
Journal:  Epilepsia       Date:  2009-10-08       Impact factor: 5.864

10.  An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Authors:  Carson C Thoreen; Seong A Kang; Jae Won Chang; Qingsong Liu; Jianming Zhang; Yi Gao; Laurie J Reichling; Taebo Sim; David M Sabatini; Nathanael S Gray
Journal:  J Biol Chem       Date:  2009-01-15       Impact factor: 5.157
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  152 in total

1.  Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2.

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Journal:  Proc Natl Acad Sci U S A       Date:  2019-08-19       Impact factor: 11.205

2.  Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation.

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Journal:  Am J Hum Genet       Date:  2019-08-15       Impact factor: 11.025

3.  Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia.

Authors:  Jae Seok Lim; Ramu Gopalappa; Se Hoon Kim; Suresh Ramakrishna; Minji Lee; Woo-Il Kim; Junho Kim; Sang Min Park; Junehawk Lee; Jung-Hwa Oh; Heung Dong Kim; Chang-Hwan Park; Joon Soo Lee; Sangwoo Kim; Dong Seok Kim; Jung Min Han; Hoon-Chul Kang; Hyongbum Henry Kim; Jeong Ho Lee
Journal:  Am J Hum Genet       Date:  2017-02-16       Impact factor: 11.025

Review 4.  New frontiers in modeling tuberous sclerosis with human stem cell-derived neurons and brain organoids.

Authors:  John D Blair; Helen S Bateup
Journal:  Dev Dyn       Date:  2019-05-23       Impact factor: 3.780

5.  Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium.

Authors:  Bo Yu; Anuoluwapo Egbejimi; Rachayata Dharmat; Pei Xu; Zhenyang Zhao; Bo Long; Hongyu Miao; Rui Chen; Theodore G Wensel; Jiyang Cai; Yan Chen
Journal:  Sci Signal       Date:  2018-05-29       Impact factor: 8.192

6.  Neuronal deletion of phosphatase and tensin homolog results in cerebellar motor learning dysfunction and alterations in intracellular signaling.

Authors:  Suzanne O Nolan; Taylor S Jefferson; Conner D Reynolds; Gregory D Smith; Andrew J Holley; Samantha L Hodges; Joaquin N Lugo
Journal:  Neuroreport       Date:  2019-05-22       Impact factor: 1.837

7.  Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio).

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Journal:  Aquat Toxicol       Date:  2018-04-18       Impact factor: 4.964

8.  A protein synthesis-dependent mechanism sustains calcium-permeable AMPA receptor transmission in nucleus accumbens synapses during withdrawal from cocaine self-administration.

Authors:  Andrew F Scheyer; Marina E Wolf; Kuei Y Tseng
Journal:  J Neurosci       Date:  2014-02-19       Impact factor: 6.167

9.  Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism.

Authors:  Arti B Patel; Irene Tsilioni; Susan E Leeman; Theoharis C Theoharides
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-23       Impact factor: 11.205

10.  Developmental changes in plasticity, synaptic, glia and connectivity protein levels in rat dorsal hippocampus.

Authors:  Alessio Travaglia; Reto Bisaz; Emmanuel Cruz; Cristina M Alberini
Journal:  Neurobiol Learn Mem       Date:  2016-08-12       Impact factor: 2.877
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