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Literature DB >> 24165175

Potential efficacy of citicoline as adjunct therapy in treatment of cerebral malaria.

Fatima El-Assaad¹, Valery Combes, Georges Emile Raymond Grau, Ronan Jambou.

Abstract

Cerebral malaria (CM) is characterized by a dysregulated immune response that results in endothelial membrane destabilization and increased microparticle (MP) production. Citicoline (CTC) is a membrane stabilizer used for the treatment of neurological disorders. We evaluated the efficacy of CTC as adjunct therapy to aid recovery from experimental CM. We show that CTC reduces MP production in vitro; in combination with artesunate in vivo, confers partial protection against CM; and prolongs survival.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2013 PMID： 24165175 PMCID： PMC3910796 DOI： 10.1128/AAC.02591-12

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

35 in total

1. Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma.

Authors: Valéry Combes; Terrie E Taylor; Irène Juhan-Vague; Jean-Louis Mège; James Mwenechanya; Madalitso Tembo; Georges E Grau; Malcolm E Molyneux
Journal: JAMA Date: 2004-06-02 Impact factor: 56.272

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Authors: Henri C van der Heyde; John Nolan; Valéry Combes; Irene Gramaglia; Georges E Grau
Journal: Trends Parasitol Date: 2006-09-18

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Journal: Apoptosis Date: 2002-04 Impact factor: 4.677

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Authors: I Lizasoain; A Cárdenas; O Hurtado; C Romera; J Mallolas; P Lorenzo; J Castillo; M A Moro
Journal: Cerebrovasc Dis Date: 2006-05-02 Impact factor: 2.762

Review 5. Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases.

Authors: Ronan Jambou; Fatima El-Assaad; Valery Combes; Georges Emile Grau
Journal: Int J Biochem Cell Biol Date: 2009-02-23 Impact factor: 5.085

6. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria.

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Journal: Science Date: 1987-09-04 Impact factor: 47.728

Review 7. Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline.

Authors: G B Weiss
Journal: Life Sci Date: 1995 Impact factor: 5.037

8. Blood-brain barrier-specific properties of a human adult brain endothelial cell line.

Authors: B B Weksler; E A Subileau; N Perrière; P Charneau; K Holloway; M Leveque; H Tricoire-Leignel; A Nicotra; S Bourdoulous; P Turowski; D K Male; F Roux; J Greenwood; I A Romero; P O Couraud
Journal: FASEB J Date: 2005-09-01 Impact factor: 5.191

Review 9. Vascular dementia: pharmacological treatment approaches and perspectives.

Authors: Andrius Baskys; Anthony C Hou
Journal: Clin Interv Aging Date: 2007 Impact factor: 4.458

10. Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model.

Authors: Jérome Dormoi; Sébastien Briolant; Camille Desgrouas; Bruno Pradines
Journal: Malar J Date: 2013-04-15 Impact factor: 2.979

3 in total