Literature DB >> 2416466

ras proteins can induce meiosis in Xenopus oocytes.

C Birchmeier, D Broek, M Wigler.   

Abstract

Injection of human H-ras protein induces maturation of Xenopus oocytes; that is, progression from prophase to metaphase of meiosis. The oncogenic protein encoded by H-rasval12 is nearly a 100-fold more potent than the protein encoded by the wild-type gene. We do not observe any measurable increase or decrease in cyclic AMP concentration in injected oocytes, and the effects of H-ras protein are only partially blocked by cholera toxin. Our results suggest that not all, if any, of the effects of H-rasval12 protein in this system are mediated by adenylate cyclase.

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Year:  1985        PMID： 2416466     DOI： 10.1016/0092-8674(85)90233-8

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  105 in total

1.  Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: inhibition of collapse by opposing mutants of rac1.

Authors:  T B Kuhn; M D Brown; C L Wilcox; J A Raper; J R Bamburg
Journal:  J Neurosci       Date:  1999-03-15       Impact factor: 6.167

2.  Prenylation of mammalian Ras protein in Xenopus oocytes.

Authors:  R Kim; J Rine; S H Kim
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

3.  Comparison of molecular dynamics averaged structures for complexes of normal and oncogenic ras-p21 with SOS nucleotide exchange protein, containing computed conformations for three crystallographically undefined domains, suggests a potential role of these domains in ras signaling.

Authors:  Thomas Duncan; James M Chen; Fred K Friedman; Mark Hyde; Lyndon Chie; Matthew R Pincus
Journal:  Protein J       Date:  2004-04       Impact factor: 2.371

4.  Loop domain peptides from the SOS ras-guanine nucleotide exchange protein, identified from molecular dynamics calculations, strongly inhibit ras signaling.

Authors:  Lyndon Chie; Fred K Friedman; Thomas Duncan; James M Chen; Denise Chung; Matthew Pincus
Journal:  Protein J       Date:  2004-04       Impact factor: 2.371

5.  H-ras(val12) induces cytoplasmic but not nuclear events of the cell cycle in small Xenopus oocytes.

Authors:  A D Johnson; R J Cork; M A Williams; K R Robinson; L D Smith
Journal:  Cell Regul       Date:  1990-06

6.  Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe.

Authors:  Y Imai; S Miyake; D A Hughes; M Yamamoto
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

7.  Specificity of inhibition of ras-p21 signal transduction by peptides from GTPase activating protein (GAP) and the son-of sevenless (SOS) ras-specific guanine nucleotide exchange protein.

Authors:  Lyndon Chie; Denise Chung; Matthew R Pincus
Journal:  Protein J       Date:  2005-05       Impact factor: 2.371

8.  Comparison of the predicted structures of loops in the ras-SOS protein bound to a single ras-p21 protein with the crystallographically determined structures in SOS bound to two ras-p21 proteins.

Authors:  Steven Smith; Mark Hyde; Matthew R Pincus
Journal:  Protein J       Date:  2005-08       Impact factor: 2.371

9.  Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway.

Authors:  B M Burgering; A J Snijders; J A Maassen; A J van der Eb; J L Bos
Journal:  Mol Cell Biol       Date:  1989-10       Impact factor: 4.272

10.  MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae.

Authors:  R Ruggieri; K Tanaka; M Nakafuku; Y Kaziro; A Toh-e; K Matsumoto
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205
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