BACKGROUND: CYP4A11 is a member of the cytochrome P450 enzymes and is responsible for metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in the regulation of blood pressure. This study aimed to evaluate whether or not the CYP4A11 gene polymorphism T8590C (rs1126742) is involved in essential hypertension in the western Chinese Han population. METHODS: In a case-control study, the participants included 864 (523 males and 341 females) patients with essential hypertension and 661 (422 males and 239 females) healthy subjects. The T8590C polymorphism of the CYP4A11 gene was analyzed by using the TaqMan® SNP Genotyping Assay. RESULTS: For men, the frequencies of the CC genotype and the C allele were higher in essential hypertension than in the control group (p=0.022 and p=0.016, respectively). After adjustment of confounding factor such as diabetes, smoking, BMI, TG and TC, the significant difference was observed in CC genotype (OR=1.897, 95% confidence interval [CI] 1.026-3.508; p=0.041). No difference was found in all participants and females. CONCLUSIONS: The CC genotype and C allele were associated with essential hypertension in the male western Chinese Han population.
BACKGROUND:CYP4A11 is a member of the cytochrome P450 enzymes and is responsible for metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in the regulation of blood pressure. This study aimed to evaluate whether or not the CYP4A11 gene polymorphism T8590C (rs1126742) is involved in essential hypertension in the western Chinese Han population. METHODS: In a case-control study, the participants included 864 (523 males and 341 females) patients with essential hypertension and 661 (422 males and 239 females) healthy subjects. The T8590C polymorphism of the CYP4A11 gene was analyzed by using the TaqMan® SNP Genotyping Assay. RESULTS: For men, the frequencies of the CC genotype and the C allele were higher in essential hypertension than in the control group (p=0.022 and p=0.016, respectively). After adjustment of confounding factor such as diabetes, smoking, BMI, TG and TC, the significant difference was observed in CC genotype (OR=1.897, 95% confidence interval [CI] 1.026-3.508; p=0.041). No difference was found in all participants and females. CONCLUSIONS: The CC genotype and C allele were associated with essential hypertension in the male western Chinese Han population.
Authors: Üzen Savas; Shouzou Wei; Mei-Hui Hsu; John R Falck; F Peter Guengerich; Jorge H Capdevila; Eric F Johnson Journal: J Biol Chem Date: 2016-06-13 Impact factor: 5.157