Literature DB >> 2416390

Kainic acid responses and toxicity show pronounced Ca2+ dependence.

N Hori, J M Ffrench-Mullen, D O Carpenter.   

Abstract

Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and a function of Ca2+ concentration, and the excitotoxic actions of various amino acid agonists are correlated with the Ca2+ dependence of their responses.

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Year:  1985        PMID： 2416390     DOI： 10.1016/0006-8993(85)90989-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

1.  Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches.

Authors:  P E Schauwecker; O Steward
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

2.  Kainic Acid Activates TRPV1 via a Phospholipase C/PIP2-Dependent Mechanism in Vitro.

Authors:  Adithya Mohandass; Bayasgalan Surenkhuu; Kyle Covington; Padmamalini Baskaran; Teresa Lehmann; Baskaran Thyagarajan
Journal:  ACS Chem Neurosci       Date:  2020-09-11       Impact factor: 4.418

3.  The release of glutamate and aspartate from rat brain synaptosomes in response to domoic acid (amnesic shellfish toxin) and kainic acid.

Authors:  J A Brown; M S Nijjar
Journal:  Mol Cell Biochem       Date:  1995-10-04       Impact factor: 3.396

4.  Responses of pyriform cortex neurons to excitatory amino acids: voltage dependence, conductance changes, and effects of divalent cations.

Authors:  N Hori; T Galeno; D O Carpenter
Journal:  Cell Mol Neurobiol       Date:  1987-03       Impact factor: 5.046
  4 in total

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