Literature DB >> 2416388

Further studies on the action of baclofen on neurons of the dorsolateral septal nucleus of the rat, in vitro.

D R Stevens, J P Gallagher, P Shinnick-Gallagher.   

Abstract

Baclofen hyperpolarizes rat dorsolateral septal neurons in a concentration-dependent manner. The apparent dissociation constant for this action is 200 nM. The baclofen-induced hyperpolarization is due to an increase in potassium conductance with a reversal potential of -88 mV. Of the various potassium and calcium channel blockers we tested, only 4-aminopyridine blocked baclofen-induced hyperpolarizations. Our results suggest that baclofen does not activate a calcium-dependent potassium conductance.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2416388     DOI： 10.1016/0006-8993(85)90984-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  Presynaptic GABAB autoreceptor modulation of P/Q-type calcium channels and GABA release in rat suprachiasmatic nucleus neurons.

Authors:  G Chen; A N van den Pol
Journal:  J Neurosci       Date:  1998-03-01       Impact factor: 6.167

2.  Bicuculline- and phaclofen-sensitive components of N-methyl-D-aspartate-induced hyperpolarizations in rat dorsolateral septal nucleus neurones.

Authors:  J P Gallagher; H Hasuo
Journal:  J Physiol       Date:  1989-11       Impact factor: 5.182

3.  Excitatory amino acid-receptor-mediated EPSPs in rat dorsolateral septal nucleus neurones in vitro.

Authors:  J P Gallagher; H Hasuo
Journal:  J Physiol       Date:  1989-11       Impact factor: 5.182

Review 4.  Spasticity and drug therapy.

Authors:  E W Wuis
Journal:  Pharm Weekbl Sci       Date:  1987-10-16

5.  On the presynaptic action of baclofen at inhibitory synapses between cultured rat hippocampal neurones.

Authors:  N L Harrison
Journal:  J Physiol       Date:  1990-03       Impact factor: 5.182

Review 6.  Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action.

Authors:  J R Howe; B Sutor; W Zieglgänsberger
Journal:  J Physiol       Date:  1987-03       Impact factor: 5.182

7.  Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze.

Authors:  E S Sidel; H A Tilson; R L McLamb; W A Wilson; H S Swartzwelder
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

8.  GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert.

Authors:  Hisahiko Kubota; Shutaro Katsurabayashi; Andrew J Moorhouse; Nobuya Murakami; Hitoshi Koga; Norio Akaike
Journal:  J Physiol       Date:  2003-06-18       Impact factor: 5.182

9.  Agonists at mu-opioid, M2-muscarinic and GABAB-receptors increase the same potassium conductance in rat lateral parabrachial neurones.

Authors:  M J Christie; R A North
Journal:  Br J Pharmacol       Date:  1988-11       Impact factor: 8.739

10.  Two inhibitory postsynaptic potentials, and GABAA and GABAB receptor-mediated responses in neocortex of rat and cat.

Authors:  B W Connors; R C Malenka; L R Silva
Journal:  J Physiol       Date:  1988-12       Impact factor: 5.182
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.