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Literature DB >> 24163790

Myocilin and Optineurin: Differential Characteristics and Functional Consequences.

Abstract

Myocilin and optineurin are two genes linked to glaucoma, a major blinding disease characterized by progressive loss of retinal ganglion cells and their axons. This review describes the characteristics of myocilin and optineurin protein products and summarizes the consequences of ectopically expressed wild type and mutant myocilin and optineurin in trabecular meshwork and/or neuronal cells. Myocilin and optineurin exhibit differential characteristics and have divergent functional consequences. They contribute to the development of glaucoma likely via distinct mechanisms.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Gene; Glaucoma; Mutation; Myocilin; Optineurin

Year: 2011 PMID： 24163790 PMCID： PMC3806134 DOI： 10.1016/j.tjo.2011.08.002

Source DB: PubMed Journal: Taiwan J Ophthalmol ISSN： 2211-5056

48 in total

1. Adult-onset primary open-angle glaucoma caused by mutations in optineurin.

Authors: Tayebeh Rezaie; Anne Child; Roger Hitchings; Glen Brice; Lauri Miller; Miguel Coca-Prados; Elise Héon; Theodore Krupin; Robert Ritch; Donald Kreutzer; R Pitts Crick; Mansoor Sarfarazi
Journal: Science Date: 2002-02-08 Impact factor: 47.728

2. Interaction of recombinant myocilin with the matricellular protein SPARC: functional implications.

Authors: José-Daniel Aroca-Aguilar; Francisco Sánchez-Sánchez; Sikha Ghosh; Ana Fernández-Navarro; Miguel Coca-Prados; Julio Escribano
Journal: Invest Ophthalmol Vis Sci Date: 2011-01-05 Impact factor: 4.799

3. Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains.

Authors: Y Li; J Kang; M S Horwitz
Journal: Mol Cell Biol Date: 1998-03 Impact factor: 4.272

4. Identification of a gene that causes primary open angle glaucoma.

Authors: E M Stone; J H Fingert; W L Alward; T D Nguyen; J R Polansky; S L Sunden; D Nishimura; A F Clark; A Nystuen; B E Nichols; D A Mackey; R Ritch; J W Kalenak; E R Craven; V C Sheffield
Journal: Science Date: 1997-01-31 Impact factor: 47.728

5. Rho GTPase and cAMP/protein kinase A signaling mediates myocilin-induced alterations in cultured human trabecular meshwork cells.

Authors: Xiang Shen; Takahisa Koga; Bum-Chan Park; Nirmala SundarRaj; Beatrice Y J T Yue
Journal: J Biol Chem Date: 2007-11-05 Impact factor: 5.157

Myocilin and Optineurin: Differential Characteristics and Functional Consequences.

1. Adult-onset primary open-angle glaucoma caused by mutations in optineurin.

2. Interaction of recombinant myocilin with the matricellular protein SPARC: functional implications.

3. Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains.

4. Identification of a gene that causes primary open angle glaucoma.

5. Rho GTPase and cAMP/protein kinase A signaling mediates myocilin-induced alterations in cultured human trabecular meshwork cells.

6. Impairment of protein trafficking upon overexpression and mutation of optineurin.

7. Overexpression of myocilin in cultured human trabecular meshwork cells.

8. Extracellular myocilin affects activity of human trabecular meshwork cells.

9. Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP.

10. NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.

1. Cellular processing of myocilin.