Literature DB >> 2416311

A peptide that inhibits the mitogenic stimulation of Swiss 3T3 cells by bombesin or vasopressin.

A N Corps, L H Rees, K D Brown.   

Abstract

The synthetic peptide [D-Arg1,D-Pro2,D-Trp7,9,Leu1]substance P inhibits the stimulation of DNA synthesis induced in Swiss 3T3 cells by bombesin or vasopressin, but not that induced by a wide range of other growth factors and mitogens. The stimulation induced by 10 pM-3 nM-bombesin is inhibited by 1-30 microM-antagonist in a manner consistent with competition at the bombesin receptor. The inhibition by the antagonist of the stimulation induced by vasopressin suggests a previously unrecognized interaction of the antagonist with vasopressin receptors. The antagonist should be useful in studies of cell proliferation both in vivo and in vitro.

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Year:  1985        PMID： 2416311      PMCID： PMC1152818          DOI： 10.1042/bj2310781

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  28 in total

1.  Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.

Authors:  C R Savage; S Cohen
Journal:  J Biol Chem       Date:  1972-12-10       Impact factor: 5.157

Review 2.  Inositol trisphosphate and diacylglycerol as second messengers.

Authors:  M J Berridge
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

3.  Reduction of epidermal growth factor receptor affinity by heterologous ligands: evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C.

Authors:  K D Brown; J Blay; R F Irvine; J P Heslop; M J Berridge
Journal:  Biochem Biophys Res Commun       Date:  1984-08-30       Impact factor: 3.575

4.  Bombesin-like activity: radioimmunologic assessment in biological tissues.

Authors:  M Brown; R Allen; J Villarreal; J Rivier; W Vale
Journal:  Life Sci       Date:  1978-12-31       Impact factor: 5.037

Review 5.  Autocrine growth factors and cancer.

Authors:  M B Sporn; A B Roberts
Journal:  Nature       Date:  1985 Feb 28-Mar 6       Impact factor: 49.962

6.  Bombesin-like peptides in rat brain: quantitation and biochemical characterization.

Authors:  T W Moody; C B Pert
Journal:  Biochem Biophys Res Commun       Date:  1979-09-12       Impact factor: 3.575

7.  Bombesin-like peptides in mammals.

Authors:  J H Walsh; H C Wong; G J Dockray
Journal:  Fed Proc       Date:  1979-08

8.  Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor.

Authors:  M J Berridge; J P Heslop; R F Irvine; K D Brown
Journal:  Biochem J       Date:  1984-08-15       Impact factor: 3.857

9.  Bombesin, neurotensin and pro-gamma-melanotropin immunoreactants in human milk.

Authors:  R Ekman; S Ivarsson; L Jansson
Journal:  Regul Pept       Date:  1985-03

10.  Bombesin-like peptides in human endocrine tumors: quantitation, biochemical characterization, and secretion.

Authors:  J Price; A C Kruseman; I Doniach; T A Howlett; G M Besser; L H Rees
Journal:  J Clin Endocrinol Metab       Date:  1985-06       Impact factor: 5.958
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  14 in total

1.  Protein kinase C-mediated negative-feedback inhibition of unstimulated and bombesin-stimulated polyphosphoinositide hydrolysis in Swiss-mouse 3T3 cells.

Authors:  K D Brown; D M Blakeley; M H Hamon; M S Laurie; A N Corps
Journal:  Biochem J       Date:  1987-08-01       Impact factor: 3.857

2.  Insulin-like synergistic stimulation of DNA synthesis in Swiss 3T3 cells by the BSC-1 cell-derived growth inhibitor related to transforming growth factor type beta.

Authors:  K D Brown; R W Holley
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

3.  Ligand-receptor interactions involved in the stimulation of Swiss 3T3 fibroblasts by insulin-like growth factors and insulin.

Authors:  A N Corps; K D Brown
Journal:  Biochem J       Date:  1988-05-15       Impact factor: 3.857

4.  Creation and functional screening of a multi-use peptide library.

Authors:  C K Jayawickreme; G F Graminski; J M Quillan; M R Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-01       Impact factor: 11.205

5.  Characterization of the high-affinity receptors on Swiss 3T3 cells which mediate the binding, internalization and degradation of the mitogenic peptide bombesin.

Authors:  K D Brown; M S Laurie; C J Littlewood; D M Blakeley; A N Corps
Journal:  Biochem J       Date:  1988-05-15       Impact factor: 3.857

6.  Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides.

Authors:  L H Wang; J F Battey; E Wada; J T Lin; S Mantey; D H Coy; R T Jensen
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

Review 7.  Neurohypophyseal peptides as regulators of growth and development. A review.

Authors:  D A Carter; C K Fai; D Murphy
Journal:  J Mol Neurosci       Date:  1993       Impact factor: 3.444

8.  Bombesin and platelet-derived growth factor stimulate formation of inositol phosphates and Ca2+ mobilization in Swiss 3T3 cells by different mechanisms.

Authors:  D M Blakeley; A N Corps; K D Brown
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

9.  [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro.

Authors:  P J Woll; E Rozengurt
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

10.  The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus.

Authors:  N Divecha; H Banfić; R F Irvine
Journal:  EMBO J       Date:  1991-11       Impact factor: 11.598
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