Literature DB >> 24162669

Regulatory T cells use "Itch" to control asthma.

WanJun Chen.   

Abstract

Regulatory T cells (Tregs) control type 2 T helper cell-mediated (Th2-mediated) lung inflammation, but the molecular mechanisms by which Tregs execute this activity remain elusive. In this issue of the JCI, Jin et al. reveal that Itch, a HECT-type E3 ubiquitin ligase in Tregs, plays a specific role in restraining Th2 cell responses. This finding has important implications for understanding the pathogenesis of allergy and asthma.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 24162669      PMCID： PMC3809809          DOI： 10.1172/JCI72477

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  18 in total

Review 1.  The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance.

Authors:  Yun-Cai Liu
Journal:  Semin Immunol       Date:  2007-04-11       Impact factor: 11.130

2.  Itch expression by Treg cells controls Th2 inflammatory responses.

Authors:  Hyung-seung Jin; Yoon Park; Chris Elly; Yun-Cai Liu
Journal:  J Clin Invest       Date:  2013-10-25       Impact factor: 14.808

3.  The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice.

Authors:  W L Perry; C M Hustad; D A Swing; T N O'Sullivan; N A Jenkins; N G Copeland
Journal:  Nat Genet       Date:  1998-02       Impact factor: 38.330

Review 4.  Development and maintenance of regulatory T cells.

Authors:  Naganari Ohkura; Yohko Kitagawa; Shimon Sakaguchi
Journal:  Immunity       Date:  2013-03-21       Impact factor: 31.745

5.  Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

Authors:  Deyu Fang; Chris Elly; Baixue Gao; Nan Fang; Yoav Altman; Claudio Joazeiro; Tony Hunter; Neal Copeland; Nancy Jenkins; Yun-Cai Liu
Journal:  Nat Immunol       Date:  2002-02-04       Impact factor: 25.606

6.  The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1.

Authors:  K Venuprasad; Haining Huang; Yousuke Harada; Chris Elly; Malayannan Subramaniam; Thomas Spelsberg; Jin Su; Yun-Cai Liu
Journal:  Nat Immunol       Date:  2008-02-17       Impact factor: 25.606

Review 7.  TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression.

Authors:  WanJun Chen; Sharon M Wahl
Journal:  Cytokine Growth Factor Rev       Date:  2003-04       Impact factor: 7.638

8.  Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.

Authors:  Ye Zheng; Ashutosh Chaudhry; Arnold Kas; Paul deRoos; Jeong M Kim; Tin-Tin Chu; Lynn Corcoran; Piper Treuting; Ulf Klein; Alexander Y Rudensky
Journal:  Nature       Date:  2009-02-01       Impact factor: 49.962

9.  Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

Authors:  F Powrie; R Correa-Oliveira; S Mauze; R L Coffman
Journal:  J Exp Med       Date:  1994-02-01       Impact factor: 14.307

10.  Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.

Authors:  WanJun Chen; Wenwen Jin; Neil Hardegen; Ke-Jian Lei; Li Li; Nancy Marinos; George McGrady; Sharon M Wahl
Journal:  J Exp Med       Date:  2003-12-15       Impact factor: 14.307
View more
  4 in total

1.  Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.

Authors:  Nandini Krishnamoorthy; Patrick R Burkett; Jesmond Dalli; Raja-Elie E Abdulnour; Romain Colas; Sesquile Ramon; Richard P Phipps; Nicos A Petasis; Vijay K Kuchroo; Charles N Serhan; Bruce D Levy
Journal:  J Immunol       Date:  2014-12-24       Impact factor: 5.422

Review 2.  Regulatory T cells in cardiovascular diseases.

Authors:  Xiao Meng; Jianmin Yang; Mei Dong; Kai Zhang; Eric Tu; Qi Gao; Wanjun Chen; Cheng Zhang; Yun Zhang
Journal:  Nat Rev Cardiol       Date:  2015-11-03       Impact factor: 32.419

3.  Helicobacter pylori neutrophil-activating protein: a potential Treg modulator suppressing allergic asthma?

Authors:  Anjna Sehrawat; Siddharth Sinha; Abhishek Saxena
Journal:  Front Microbiol       Date:  2015-06-01       Impact factor: 5.640

4.  Astragaloside IV Ameliorates Airway Inflammation in an Established Murine Model of Asthma by Inhibiting the mTORC1 Signaling Pathway.

Authors:  Hualiang Jin; Limin Wang; Bei Li; Cui Cai; Jian Ye; Junbo Xia; Shenglin Ma
Journal:  Evid Based Complement Alternat Med       Date:  2017-10-25       Impact factor: 2.629
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.