Literature DB >> 2416121

Immunogenic and antigenic epitopes of immunoglobulins. X: Monoclonal antibodies specific for human IgA, the IgA1 and IgA2 subclasses and an nA2m(2) iso-allotypic epitope.

M A Farris, D Hardie, G de Lange, R Jefferis.   

Abstract

Monoclonal antibodies (McAb) specific for human IgA, the IgA1 and IgA2 subclasses and the iso-allotypic epitope nA2m(2) have been produced. Three distinct McAb recognize an IgA1-specific epitope expressed in the C alpha 2 domain or the hinge region whilst a further McAb is directed possibly to an IgA1 hinge region epitope. The McAb having nA2m(2) specificity recognizes an iso-allotypic epitope expressed within the Fab region. IgA1 and IgA2 epitopes were detected in gorilla but not rhesus or baboon sera suggesting that the IgA subclasses represent a recent gene duplication even. However, these epitopes were also detected in some non-primate sera.

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Year:  1985        PMID： 2416121     DOI： 10.1111/j.1423-0410.1985.tb00155.x

Source DB:  PubMed          Journal:  Vox Sang        ISSN： 0042-9007            Impact factor:   2.144


  9 in total

1.  Lack of cleavage of immunoglobulin A (IgA) from rhesus monkeys by bacterial IgA1 proteases.

Authors:  J Reinholdt; M Kilian
Journal:  Infect Immun       Date:  1991-06       Impact factor: 3.441

2.  Large scale generation and characterization of anti-human IgA monoclonal antibody in ascitic fluid of BALB/c mice.

Authors:  Fatemeh Ezzatifar; Jafar Majidi; Behzad Baradaran; Leili Aghebati Maleki; Jalal Abdolalizadeh; Mehdi Yousefi
Journal:  Adv Pharm Bull       Date:  2015-03-05

3.  Individual variation in the isotype profile of anti-histone autoantibodies in systemic lupus erythematosus.

Authors:  G Fellows; N Gittoes; D G Scott; J S Coppock; A Wainwright; M Goodall; B M Turner
Journal:  Clin Exp Immunol       Date:  1988-06       Impact factor: 4.330

4.  Cells containing IgA subclasses in bronchi of subjects with and without chronic obstructive lung disease.

Authors:  D Burnett; J Crocker; R A Stockley
Journal:  J Clin Pathol       Date:  1987-10       Impact factor: 3.411

5.  Restricted light chain subgroup expression on human rheumatoid factor paraproteins determined by monoclonal antibodies.

Authors:  R A Mageed; M R Walker; R Jefferis
Journal:  Immunology       Date:  1986-11       Impact factor: 7.397

6.  Development of a high-sensitivity ELISA detecting IgG, IgA and IgM antibodies to the SARS-CoV-2 spike glycoprotein in serum and saliva.

Authors:  Sian E Faustini; Sian E Jossi; Marisol Perez-Toledo; Adrian M Shields; Joel D Allen; Yasunori Watanabe; Maddy L Newby; Alex Cook; Carrie R Willcox; Mahboob Salim; Margaret Goodall; Jennifer L Heaney; Edith Marcial-Juarez; Gabriella L Morley; Barbara Torlinska; David C Wraith; Tonny V Veenith; Stephen Harding; Stephen Jolles; Mark J Ponsford; Tim Plant; Aarnoud Huissoon; Matthew K O'Shea; Benjamin E Willcox; Mark T Drayson; Max Crispin; Adam F Cunningham; Alex G Richter
Journal:  Immunology       Date:  2021-05-24       Impact factor: 7.215

7.  Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.

Authors:  M Brüggemann; G T Williams; C I Bindon; M R Clark; M R Walker; R Jefferis; H Waldmann; M S Neuberger
Journal:  J Exp Med       Date:  1987-11-01       Impact factor: 14.307

8.  Primary breast cancer tumours contain high amounts of IgA1 immunoglobulin: an immunohistochemical analysis of a possible carrier of the tumour-associated Tn antigen.

Authors:  Charlotte Welinder; Bo Baldetorp; Ola Blixt; Dorthe Grabau; Bo Jansson
Journal:  PLoS One       Date:  2013-04-18       Impact factor: 3.240

9.  Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

Authors:  Charlotte Welinder; Karin Jirström; Sophie Lehn; Björn Nodin; György Marko-Varga; Ola Blixt; Lena Danielsson; Bo Jansson
Journal:  Heliyon       Date:  2016-08-16
  9 in total

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