Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment.

Literature DB >> 2416056

A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment.

Abstract

Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations of the pregnane nucleus. These compounds are here named angiostatic steroids.

Entities: Chemical

Mesh：

Substances：

Year: 1985 PMID： 2416056 DOI： 10.1126/science.2416056

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

59 in total

1. The role of the vascular phase in solid tumor growth: a historical review.

Authors: D Ribatti; A Vacca; F Dammacco
Journal: Neoplasia Date: 1999-10 Impact factor: 5.715

2. Cyclopeptide RA-V inhibits angiogenesis by down-regulating ERK1/2 phosphorylation in HUVEC and HMEC-1 endothelial cells.

Authors: Grace G L Yue; Jun-Ting Fan; Julia K M Lee; Guang-Zhi Zeng; Tina W F Ho; Kwok-Pui Fung; Ping-Chung Leung; Ning-Hua Tan; Clara B S Lau
Journal: Br J Pharmacol Date: 2011-12 Impact factor: 8.739

8. Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis).

Authors: Dimitri T Azar
Journal: Trans Am Ophthalmol Soc Date: 2006

9. The use of angiostatic steroids to inhibit cartilage destruction in an in vivo model of granuloma-mediated cartilage degradation.

Authors: P R Colville-Nash; M el-Ghazaly; D A Willoughby
Journal: Agents Actions Date: 1993-01

10. Curcumin inhibits angiogenesis by up-regulation of microRNA-1275 and microRNA-1246: a promising therapy for treatment of corneal neovascularization.

Authors: Yanhui Bai; Weiqun Wang; Guangli Sun; Mingchang Zhang; Jingmin Dong
Journal: Cell Prolif Date: 2016-09-14 Impact factor: 6.831

A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment.

1. The role of the vascular phase in solid tumor growth: a historical review.

2. Cyclopeptide RA-V inhibits angiogenesis by down-regulating ERK1/2 phosphorylation in HUVEC and HMEC-1 endothelial cells.

3. Antiangiogenic, antimicrobial, and cytotoxic potential of sponge-associated bacteria.

Review 4. Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease.

Review 5. Application of polysaccharides for surface modification of nanomedicines.

6. Induction of vascular endothelial tubular morphogenesis by human glioma cells. A model system for tumor angiogenesis.

7. Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

8. Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis).

9. The use of angiostatic steroids to inhibit cartilage destruction in an in vivo model of granuloma-mediated cartilage degradation.

10. Curcumin inhibits angiogenesis by up-regulation of microRNA-1275 and microRNA-1246: a promising therapy for treatment of corneal neovascularization.