Literature DB >> 241595

Simultaneous pharmacokinetics of alclofenace in plasma and synovial fluid in patients with rheumatoid arthritis.

G M Thomas, P Rees, J E Dippy, J Maddock.   

Abstract

The simultaneous pharmacokinetics of alclofenac in the plasma and synovial fluid of 10 patients with rheumatoid arthritis were studied after a single 1 g. oral dose. A gas-liquid chromatographic method was used for assaying alclofenac in both plasma and synovial fluid. Alclofenac readily appears in the plasma and synovial fluid.

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Year:  1975        PMID： 241595     DOI： 10.1185/03007997509114776

Source DB:  PubMed          Journal:  Curr Med Res Opin        ISSN： 0300-7995            Impact factor:   2.580


  9 in total

1.  Alclofenac: a review of its pharmacological properties and therapeutic efficacy in rheumatoid arthritis and allied rheumatic disorders.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1977-10       Impact factor: 9.546

Review 2.  Correlation plasma levels, NSAID and therapeutic response.

Authors:  J P Famaey
Journal:  Clin Rheumatol       Date:  1985-06       Impact factor: 2.980

Review 3.  Articular pharmacokinetics of protein-bound antirheumatic agents.

Authors:  P A Simkin; M P Wu; D M Foster
Journal:  Clin Pharmacokinet       Date:  1993-10       Impact factor: 6.447

4.  Diffusion of oxyphenbutazone into synovial fluid, synovial tissue, joint cartilage and cerebrospinal fluid.

Authors:  A Gaucher; P Netter; G Faure; J P Schoeller; A Gerardin
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

Review 5.  Antirheumatic drug concentrations in human synovial fluid and synovial tissue. Observations on extravascular pharmacokinetics.

Authors:  W J Wallis; P A Simkin
Journal:  Clin Pharmacokinet       Date:  1983 Nov-Dec       Impact factor: 6.447

6.  Protein binding of non-steroidal anti-inflammatory drugs in plasma and synovial fluid of arthritic patients.

Authors:  S Wanwimolruk; P M Brooks; D J Birkett
Journal:  Br J Clin Pharmacol       Date:  1983-01       Impact factor: 4.335

7.  Pharmacokinetic Assessment of Staphylococcal Phage K Following Parenteral and Intra-articular Administration in Rabbits.

Authors:  Katherine M C Totten; Scott A Cunningham; Naomi M Gades; Athema Etzioni; Robin Patel
Journal:  Front Pharmacol       Date:  2022-05-20       Impact factor: 5.988

Review 8.  Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs.

Authors:  J H Lin; D M Cocchetto; D E Duggan
Journal:  Clin Pharmacokinet       Date:  1987-06       Impact factor: 6.447

Review 9.  Clinical pharmacokinetics of non-steroidal anti-inflammatory drugs.

Authors:  R K Verbeeck; J L Blackburn; G R Loewen
Journal:  Clin Pharmacokinet       Date:  1983 Jul-Aug       Impact factor: 6.447
  9 in total

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