BACKGROUND: In industrialised countries, approximately 5-20% of women smoke during pregnancy. We aim to study the association between smoking during pregnancy and adverse perinatal outcomes. METHODS: A retrospective population-based cohort study using data on all singleton births between 1991 and 2010 (n=1,164,953) derived from the Finnish Medical Birth Register. RESULTS: Of all the mothers included, 82.3% were non-smokers, 2.6% quit smoking during the first trimester of pregnancy, 12.5% smoked throughout pregnancy and 2.7% had no information on smoking. Continuing smoking after the first trimester of the pregnancy was associated with an increased prevalence of admission to a neonatal intensive care unit, stillbirth, preterm birth (<37 gestational weeks), low birth weight (LBW, <2500 g), small for gestational age (SGA, < -2 SDs) and major congenital anomaly compared with non-smokers. Smoking cessation reduced the risk of prematurity, stillbirth, LBW and SGA close to or at similar levels as those of non-smokers. Tobacco exposure in early pregnancy resulted in a 19% increased prevalence of admission to neonatal intensive care unit and a 22% increased prevalence of major congenital anomaly compared with non-smokers. CONCLUSIONS: Smoking cessation appeared to reduce pregnancy risks close to those of non-smoking peers. Exposure to early pregnancy smoking was, however, associated with an increased admission to neonatal intensive care and an increased prevalence of major congenital anomalies.
BACKGROUND: In industrialised countries, approximately 5-20% of women smoke during pregnancy. We aim to study the association between smoking during pregnancy and adverse perinatal outcomes. METHODS: A retrospective population-based cohort study using data on all singleton births between 1991 and 2010 (n=1,164,953) derived from the Finnish Medical Birth Register. RESULTS: Of all the mothers included, 82.3% were non-smokers, 2.6% quit smoking during the first trimester of pregnancy, 12.5% smoked throughout pregnancy and 2.7% had no information on smoking. Continuing smoking after the first trimester of the pregnancy was associated with an increased prevalence of admission to a neonatal intensive care unit, stillbirth, preterm birth (<37 gestational weeks), low birth weight (LBW, <2500 g), small for gestational age (SGA, < -2 SDs) and major congenital anomaly compared with non-smokers. Smoking cessation reduced the risk of prematurity, stillbirth, LBW and SGA close to or at similar levels as those of non-smokers. Tobacco exposure in early pregnancy resulted in a 19% increased prevalence of admission to neonatal intensive care unit and a 22% increased prevalence of major congenital anomaly compared with non-smokers. CONCLUSIONS: Smoking cessation appeared to reduce pregnancy risks close to those of non-smoking peers. Exposure to early pregnancy smoking was, however, associated with an increased admission to neonatal intensive care and an increased prevalence of major congenital anomalies.
Authors: Lisette T Jacobson; Philip Twumasi-Ankrah; Michelle L Redmond; Elizabeth Ablah; Robert B Hines; Judy Johnston; Tracie C Collins Journal: Matern Child Health J Date: 2015-04
Authors: Elizabeth Moore; Kaitlin Blatt; Aimin Chen; James Van Hook; Emily A DeFranco Journal: Am J Obstet Gynecol Date: 2016-01-28 Impact factor: 8.661