OBJECTIVE: Cerebrospinal fluid (CSF) amyloid β42 (Aβ42), total tau (t-tau) and phosphorylated tau (p-tau) are useful as predictors of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. However, results are contradictory as to whether these biomarkers reflect the future rate of clinical decline. METHODS: This is a retrospective study on 196 patients with AD [mild/moderate AD (n = 72) or AD-MCI (n = 124) at baseline] with a follow-up period of 2-9 years' duration (median 6 years). Lumbar punctures were performed at baseline as a part of the diagnostic procedure. RESULTS: We found an increased risk of rapid cognitive decline defined as a drop in the Mini-Mental State Examination score of ≥ 4 points/year in patients with CSF t-tau concentrations above the median (OR 3.31, 95% CI 1.53-7.16) and CSF p-tau above the median (OR 2.53, 95% CI 1.21-5.26). Patients with CSF t-tau in the highest quartile had a higher risk of dying in severe dementia (HR 4.67, 95% CI 1.16-18.82). CONCLUSIONS: In this large AD cohort, we found an association between high levels of CSF t-tau and p-tau and a more aggressive course of the disease, measured as a rapid cognitive decline and a higher risk of dying in severe dementia.
OBJECTIVE: Cerebrospinal fluid (CSF) amyloid β42 (Aβ42), total tau (t-tau) and phosphorylated tau (p-tau) are useful as predictors of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. However, results are contradictory as to whether these biomarkers reflect the future rate of clinical decline. METHODS: This is a retrospective study on 196 patients with AD [mild/moderate AD (n = 72) or AD-MCI (n = 124) at baseline] with a follow-up period of 2-9 years' duration (median 6 years). Lumbar punctures were performed at baseline as a part of the diagnostic procedure. RESULTS: We found an increased risk of rapid cognitive decline defined as a drop in the Mini-Mental State Examination score of ≥ 4 points/year in patients with CSF t-tau concentrations above the median (OR 3.31, 95% CI 1.53-7.16) and CSF p-tau above the median (OR 2.53, 95% CI 1.21-5.26). Patients with CSF t-tau in the highest quartile had a higher risk of dying in severe dementia (HR 4.67, 95% CI 1.16-18.82). CONCLUSIONS: In this large AD cohort, we found an association between high levels of CSF t-tau and p-tau and a more aggressive course of the disease, measured as a rapid cognitive decline and a higher risk of dying in severe dementia.
Authors: Panagiotis Alexopoulos; Lukas Werle; Jennifer Roesler; Nathalie Thierjung; Lena Sophie Gleixner; Igor Yakushev; Nikolaos Laskaris; Stefan Wagenpfeil; Philippos Gourzis; Alexander Kurz; Robert Perneczky Journal: Alzheimers Res Ther Date: 2016-12-09 Impact factor: 6.982
Authors: Malin Degerman Gunnarsson; Martin Ingelsson; Kaj Blennow; Hans Basun; Lars Lannfelt; Lena Kilander Journal: Alzheimers Res Ther Date: 2016-06-06 Impact factor: 6.982
Authors: Hanneke F M Rhodius-Meester; Hilkka Liedes; Ted Koene; Afina W Lemstra; Charlotte E Teunissen; Frederik Barkhof; Philip Scheltens; Mark van Gils; Jyrki Lötjönen; Wiesje M van der Flier Journal: Alzheimers Res Ther Date: 2018-02-20 Impact factor: 6.982