BACKGROUND/AIMS: To investigate the association between VEGF gene polymorphism and response to ranibizumab in neovascular age-related macular degeneration (AMD). METHODS: A total of 92 patients were genotyped for the VEGF rs1413711 single nucleotide polymorphism. Patients with neovascular AMD initially received 3 monthly ranibizumab intravitreal injections and were retreated as needed. Visual acuity (VA) and central retinal thickness (CRT) were measured before and 1, 3, 6 and 12 months after treatment. RESULTS: For patients with TT and CT genotypes, paired comparisons of mean VA showed improvement when the data obtained at all visits were compared with baseline values, in contrast to patients with the CC genotype. CRT statistically improved at all visits for all genotypes. CONCLUSION: Patients with the CC genotype showed poorer long-term functional and anatomical response to anti-VEGF therapy.
BACKGROUND/AIMS: To investigate the association between VEGF gene polymorphism and response to ranibizumab in neovascular age-related macular degeneration (AMD). METHODS: A total of 92 patients were genotyped for the VEGFrs1413711 single nucleotide polymorphism. Patients with neovascular AMD initially received 3 monthly ranibizumab intravitreal injections and were retreated as needed. Visual acuity (VA) and central retinal thickness (CRT) were measured before and 1, 3, 6 and 12 months after treatment. RESULTS: For patients with TT and CT genotypes, paired comparisons of mean VA showed improvement when the data obtained at all visits were compared with baseline values, in contrast to patients with the CC genotype. CRT statistically improved at all visits for all genotypes. CONCLUSION:Patients with the CC genotype showed poorer long-term functional and anatomical response to anti-VEGF therapy.
Authors: Un Chul Park; Joo Young Shin; Linda C McCarthy; Sang Jin Kim; Jung Hyun Park; Hum Chung; Hyeong Gon Yu Journal: Mol Vis Date: 2014-12-19 Impact factor: 2.367
Authors: Haibo Wang; Xiaokun Han; Colin A Bretz; Silke Becker; Deeksha Gambhir; George W Smith; R Jude Samulski; Erika S Wittchen; Lawrence A Quilliam; Magdalena Chrzanowska-Wodnicka; M Elizabeth Hartnett Journal: Mol Ther Methods Clin Dev Date: 2016-08-24 Impact factor: 6.698