Ian C Y Chang1, Erin Austin2, Balaji Krishnan1, David G Benditt1, Chwee N Quay3, Lieng H Ling4, Lin Y Chen5. 1. Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA. 2. Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA. 3. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 4. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiac Department, National University Heart Centre, Singapore. 5. Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: chenx484@umn.edu.
Abstract
BACKGROUND AND PURPOSE: Prolonged P-wave dispersion (PWD) and P-wave duration (PWdur) have been found to be associated with common atrial fibrillation (AF), but the association of P-wave indices with lone atrial fibrillation (LAF) is unclear. METHODS: We enrolled 61 paroxysmal LAF cases and 150 controls without AF. P-wave indices were measured from a 12-lead ECG. Multivariable logistic regression was used to assess the association between P-wave indices and LAF. RESULTS: PWD was longer in LAF patients (median, IQR; 54.1 [42.9-63.2] ms) than controls (46.0 [38.5-57.7] ms), P=0.03. MinPWdur was shorter in LAF patients (60.5 [50.7-72.6] ms) than controls (66.0 [55.5-76.4] ms), P=0.03. In multivariable models, only the association between shorter minPWdur and LAF remained statistically significant (OR [95% CI] per tertile increment in minPWdur, 0.64 [0.42-0.95], P=0.03). CONCLUSIONS: Unlike common AF, paroxysmal LAF is independently associated with shorter minPWdur. This finding suggests that both shorter and prolonged PWdur may be associated with increased risk of AF.
BACKGROUND AND PURPOSE: Prolonged P-wave dispersion (PWD) and P-wave duration (PWdur) have been found to be associated with common atrial fibrillation (AF), but the association of P-wave indices with lone atrial fibrillation (LAF) is unclear. METHODS: We enrolled 61 paroxysmal LAF cases and 150 controls without AF. P-wave indices were measured from a 12-lead ECG. Multivariable logistic regression was used to assess the association between P-wave indices and LAF. RESULTS: PWD was longer in LAF patients (median, IQR; 54.1 [42.9-63.2] ms) than controls (46.0 [38.5-57.7] ms), P=0.03. MinPWdur was shorter in LAF patients (60.5 [50.7-72.6] ms) than controls (66.0 [55.5-76.4] ms), P=0.03. In multivariable models, only the association between shorter minPWdur and LAF remained statistically significant (OR [95% CI] per tertile increment in minPWdur, 0.64 [0.42-0.95], P=0.03). CONCLUSIONS: Unlike common AF, paroxysmal LAF is independently associated with shorter minPWdur. This finding suggests that both shorter and prolonged PWdur may be associated with increased risk of AF.
Authors: Lin Yee Chen; Antonio Luiz Pinho Ribeiro; Pyotr G Platonov; Iwona Cygankiewicz; Elsayed Z Soliman; Bulent Gorenek; Takanori Ikeda; Vassilios P Vassilikos; Jonathan S Steinberg; Niraj Varma; Antoni Bayés-de-Luna; Adrian Baranchuk Journal: Circ Arrhythm Electrophysiol Date: 2022-03-25
Authors: Angelo Auricchio; Tardu Özkartal; Francesca Salghetti; Laura Neumann; Simone Pezzuto; Ali Gharaviri; Andrea Demarchi; Maria Luce Caputo; François Regoli; Carlo De Asmundis; Gian-Battista Chierchia; Pedro Brugada; Catherine Klersy; Tiziano Moccetti; Ulrich Schotten; Giulio Conte Journal: J Am Heart Assoc Date: 2021-01-07 Impact factor: 5.501