Literature DB >> 24157070

Least-squares deconvolution of evoked potentials and sequence optimization for multiple stimuli under low-jitter conditions.

Fabrice Bardy1, Harvey Dillon2, Bram Van Dun2.   

Abstract

OBJECTIVE: Rapid presentation of stimuli in an evoked response paradigm can lead to overlap of multiple responses and consequently difficulties interpreting waveform morphology. This paper presents a deconvolution method allowing overlapping multiple responses to be disentangled.
METHODS: The deconvolution technique uses a least-squared error approach. A methodology is proposed to optimize the stimulus sequence associated with the deconvolution technique under low-jitter conditions. It controls the condition number of the matrices involved in recovering the responses. Simulations were performed using the proposed deconvolution technique.
RESULTS: Multiple overlapping responses can be recovered perfectly in noiseless conditions. In the presence of noise, the amount of error introduced by the technique can be controlled a priori by the condition number of the matrix associated with the used stimulus sequence. The simulation results indicate the need for a minimum amount of jitter, as well as a sufficient number of overlap combinations to obtain optimum results. An aperiodic model is recommended to improve reconstruction.
CONCLUSIONS: We propose a deconvolution technique allowing multiple overlapping responses to be extracted and a method of choosing the stimulus sequence optimal for response recovery. SIGNIFICANCE: This technique may allow audiologists, psychologists, and electrophysiologists to optimize their experimental designs involving rapidly presented stimuli, and to recover evoked overlapping responses.
Copyright © 2013 International Federation of Clinical Neurophysiology. All rights reserved.

Keywords:  Least-squares (LS) deconvolution; Low-jitter; Multiple stimuli; Optimization of stimulus sequence

Mesh:

Year:  2013        PMID: 24157070     DOI: 10.1016/j.clinph.2013.09.030

Source DB:  PubMed          Journal:  Clin Neurophysiol        ISSN: 1388-2457            Impact factor:   3.708


  4 in total

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Authors:  Anne Guérin-Dugué; Raphaëlle N Roy; Emmanuelle Kristensen; Bertrand Rivet; Laurent Vercueil; Anna Tcherkassof
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4.  Deconvolution of Ears' Activity (DEA): A New Experimental Paradigm to Investigate Central Auditory Processing.

Authors:  Fabrice Bardy
Journal:  Front Syst Neurosci       Date:  2022-07-14
  4 in total

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