Literature DB >> 2415658

Tolerance to parenchymal self. Regulatory role of major histocompatibility complex-restricted, OX8+ suppressor T cells specific for autologous renal tubular antigen in experimental interstitial nephritis.

C J Kelly, W K Silvers, E G Neilson.   

Abstract

BN rats develop interstitial nephritis after immunization with rabbit, but not rat renal tubular antigen. Using RT1n rat strains that differentially express tubular antigen, we investigated the unresponsiveness of BN rats to BN tubular antigen (BN-TBM) using delayed-type hypersensitivity (DTH) responses to BN-TBM as a measure of cell-mediated immunity. Our results indicate that rat strains expressing tubular antigen respond to immunization with BN-TBM with the clonal expansion of antigen-specific, cyclophosphamide-sensitive, OX8+, MHC-restricted suppressor T cells. Such suppression appears to be relevant to the maintenance of tolerance to parenchymal self, since chronic cyclophosphamide therapy abrogates suppression and results in significant interstitial nephritis.

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Year:  1985        PMID： 2415658      PMCID： PMC2187971          DOI： 10.1084/jem.162.6.1892

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  33 in total

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Authors:  P J Kilshaw; L Brent; M Pinto
Journal:  Nature       Date:  1975-06-05       Impact factor: 49.962

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Authors:  J F Miller; M A Vadas; A Whitelaw; J Gamble
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

3.  Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes.

Authors:  A F Williams; G Galfrè; C Milstein
Journal:  Cell       Date:  1977-11       Impact factor: 41.582

4.  "Panning" for lymphocytes: a method for cell selection.

Authors:  L J Wysocki; V L Sato
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

5.  A rapid method for the isolation of functional thymus-derived murine lymphocytes.

Authors:  M H Julius; E Simpson; L A Herzenberg
Journal:  Eur J Immunol       Date:  1973-10       Impact factor: 5.532

6.  Role of T lymphocytes in adjuvant arthritis. II. Different subpopulations of T lymphocytes functioning in the development of the disease.

Authors:  K Kayashima; T Koga; K Onoue
Journal:  J Immunol       Date:  1978-04       Impact factor: 5.422

Review 7.  Cellular mechanisms of immunologic tolerance.

Authors:  G J Nossal
Journal:  Annu Rev Immunol       Date:  1983       Impact factor: 28.527

8.  Immune suppression with supraoptimal doses of antigen in contact sensitivity. I. Demonstration of suppressor cells and their sensitivity to cyclophosphamide.

Authors:  M S Sy; S D Miller; H N Claman
Journal:  J Immunol       Date:  1977-07       Impact factor: 5.422

9.  Enrichment of specific suppressor T cells and characterization of their surface markers.

Authors:  M Taniguchi; J F Miller
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307

10.  Recirculating, suppressor T cells in transplantation tolerance.

Authors:  S Dorsch; R Roser
Journal:  J Exp Med       Date:  1977-05-01       Impact factor: 14.307
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  8 in total

Review 1.  Contrasuppression in autoimmunity.

Authors:  C J Kelly; E G Neilson
Journal:  Immunol Res       Date:  1988       Impact factor: 2.829

2.  Molecular characterization of a major nephritogenic domain in the autoantigen of anti-tubular basement membrane disease.

Authors:  E G Neilson; M J Sun; C J Kelly; W H Hines; T P Haverty; M D Clayman; N E Cooke
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

3.  Mercuric chloride-induced autoimmunity in the brown Norway rat. Cellular kinetics and major histocompatibility complex antigen expression.

Authors:  J Aten; C B Bosman; J Rozing; T Stijnen; P J Hoedemaeker; J J Weening
Journal:  Am J Pathol       Date:  1988-10       Impact factor: 4.307

4.  Inhibition of murine nephritogenic effector T cells by a clone-specific suppressor factor.

Authors:  C M Meyers; C J Kelly
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

5.  Prostaglandin E1 inhibits effector T cell induction and tissue damage in experimental murine interstitial nephritis.

Authors:  C J Kelly; R B Zurier; K A Krakauer; N Blanchard; E G Neilson
Journal:  J Clin Invest       Date:  1987-03       Impact factor: 14.808

6.  Autoimmune interstitial nephritis induced in inbred mice. Analysis of mouse tubular basement membrane antigen and genetic control of immune response to it.

Authors:  S Ueda; M Wakashin; Y Wakashin; H Yoshida; R Azemoto; K Iesato; T Mori; Y Mori; M Ogawa; K Okuda
Journal:  Am J Pathol       Date:  1988-08       Impact factor: 4.307

7.  Selective planting of cationized, haptenized ovalbumin on the rat tubular basement membrane.

Authors:  K Joh; S Aizawa; K Ohkawa; T Morioka; T Oite; F Shimizu; S Batsford; A Vogt
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

8.  Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.

Authors:  D Lo; L C Burkly; R A Flavell; R D Palmiter; R L Brinster
Journal:  J Exp Med       Date:  1989-07-01       Impact factor: 14.307
  8 in total

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