Literature DB >> 2415644

Identification of a specific epitope of Haemophilus influenzae on a 16,600-dalton outer membrane protein.

T F Murphy, M B Nelson, K C Dudas, J M Mylotte, M A Apicella.   

Abstract

A mouse monoclonal antibody that recognizes an epitope on a 16,600-dalton outer membrane protein was developed to nontypable Haemophilus influenzae. This epitope was present on all 115 isolates of H. influenzae tested, including typable and nontypable strains. Screening of 89 strains of other bacteria demonstrated that this epitope is a highly specific marker for H. influenzae because the epitope was absent in virtually all other bacterial species tested. Western blot assays were performed with two normal human serum samples and convalescent-phase serum from an adult with bacteremia due to nontypable H. influenzae. Antibody to the 16,600-dalton outer membrane protein was present in all three human serum samples.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2415644     DOI： 10.1093/infdis/152.6.1300

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  43 in total

1.  Neonatal, urogenital isolates of biotype 4 nontypeable Haemophilus influenzae express a variant P6 outer membrane protein molecule.

Authors:  T F Murphy; C Kirkham; D J Sikkema
Journal:  Infect Immun       Date:  1992-05       Impact factor: 3.441

Review 2.  Molecular biology and respiratory disease. 6. Modern molecular biology and respiratory bacterial infections: a revolution on the horizon.

Authors:  T F Murphy
Journal:  Thorax       Date:  1990-07       Impact factor: 9.139

3.  Cloning of genes encoding a 15,000-dalton peptidoglycan-associated outer membrane lipoprotein and an antigenically related 15,000-dalton protein from Haemophilus influenzae.

Authors:  R A Deich; B J Metcalf; C W Finn; J E Farley; B A Green
Journal:  J Bacteriol       Date:  1988-02       Impact factor: 3.490

4.  Antigenic conservation of the 15,000-dalton outer membrane lipoprotein PCP of Haemophilus influenzae and biologic activity of anti-PCP antisera.

Authors:  R A Deich; A Anilionis; J Fulginiti; B J Metcalf; S Quataert; T Quinn-Dey; G W Zlotnick; B A Green
Journal:  Infect Immun       Date:  1990-10       Impact factor: 3.441

5.  Conserved and nonconserved epitopes among Haemophilus influenzae type b pili.

Authors:  J R Gilsdorf; K McCrea; L Forney
Journal:  Infect Immun       Date:  1990-07       Impact factor: 3.441

6.  Haemophilus influenzae vaccine candidate outer membrane protein P6 is not conserved in all strains.

Authors:  Arthur Chang; Ravinder Kaur; Lea Vacca Michel; Janet R Casey; Michael Pichichero
Journal:  Hum Vaccin       Date:  2011-01-01

7.  Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells.

Authors:  T Shuto; H Xu; B Wang; J Han; H Kai; X X Gu; T F Murphy; D J Lim; J D Li
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

8.  Cloning of the gene encoding the major outer membrane protein of Haemophilus influenzae type b.

Authors:  E J Hansen; F R Gonzales; N R Chamberlain; M V Norgard; E E Miller; L D Cope; S E Pelzel; B Gaddy; A Clausell
Journal:  Infect Immun       Date:  1988-10       Impact factor: 3.441

9.  Lipoproteins of Haemophilus influenzae type b.

Authors:  G A Weinberg; D A Towler; R S Munson
Journal:  J Bacteriol       Date:  1988-09       Impact factor: 3.490

10.  Mapping of a surface-exposed, conformational epitope of the P6 protein of Haemophilus influenzae.

Authors:  J A Bogdan; M A Apicella
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.