| Literature DB >> 24156081 |
M Mazurenka1, L Di Sieno, G Boso, D Contini, A Pifferi, A Dalla Mora, A Tosi, H Wabnitz, R Macdonald.
Abstract
We report on the design and first in vivo tests of a novel non-contact scanning imaging system for time-domain near-infrared spectroscopy. Our system is based on a null source-detector separation approach and utilizes polarization-selective detection and a fast-gated single-photon avalanche diode to record late photons only. The in-vivo tests included the recording of hemodynamics during arm occlusion and two brain activation tasks. Localized and non-localized changes in oxy- and deoxyhemoglobin concentration were detected for motor and cognitive tasks, respectively. The tests demonstrate the feasibility of non-contact imaging of absorption changes in deeper tissues.Keywords: (120.3890) Medical optics instrumentation; (170.3880) Medical and biological imaging; (170.5280) Photon migration; (170.6510) Spectroscopy, tissue diagnostics; (170.6920) Time-resolved imaging
Year: 2013 PMID: 24156081 PMCID: PMC3799683 DOI: 10.1364/BOE.4.002257
Source DB: PubMed Journal: Biomed Opt Express ISSN: 2156-7085 Impact factor: 3.732