| Literature DB >> 24155041 |
Paolo Mellini1, Vincenzo Carafa, Barbara Di Rienzo, Dante Rotili, Daniela De Vita, Roberto Cirilli, Bruno Gallinella, Donatella Paola Provvisiero, Salvatore Di Maro, Ettore Novellino, Lucia Altucci, Antonello Mai.
Abstract
The best of both: SIRT1/2 inhibitors were developed by combining chemical features of selisistat (SIRT1-selective inhibitor; blue) and carprofen (anti-inflammatory drug; red). The most potent compound (shown) increased acetyl-p53 and acetyl-α-tubulin levels, and induced slight apoptosis at 50 μM in U937 cells, differently from selisistat and carprofen.Entities:
Keywords: SIRT1/2; apoptosis; histone deacetylases; inhibitors; sirtuins
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Year: 2012 PMID： 24155041 DOI： 10.1002/cmdc.201200318
Source DB: PubMed Journal: ChemMedChem ISSN： 1860-7179 Impact factor: 3.466