Literature DB >> 24155022

A study of analytical methods for the determination of propofol in blood.

Eunyoung Han1.   

Abstract

Propofol (2,6-diisopropylphenol) is a commonly used short-acting intravenous anesthetic agent. However, because of the risk of drug abuse and propofol related death, in Korea propofol is a controlled drug. In this review, the analytical methods using liquid chromatography (LC), gas chromatography/mass spectrometry, or LC coupled with tandem mass spectrometry to detect and quantify propofol or its metabolites in blood were described. The validation data for the analytical methods and propofol concentrations in the blood were reviewed.

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Year:  2013        PMID: 24155022     DOI: 10.1007/s12272-013-0265-5

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN: 0253-6269            Impact factor:   4.946


  4 in total

Review 1.  [Brain death diagnosis after sedation with propofol or sufentanil. Recommendations for the usage of toxicological analytics].

Authors:  U Walter; U Brüderlein; M Gloger; S Mann; U Walther
Journal:  Med Klin Intensivmed Notfmed       Date:  2014-09-26       Impact factor: 0.840

2.  Rapid determination and continuous monitoring of propofol in microliter whole blood sample during anesthesia by paper spray ionization-mass spectrometry.

Authors:  Ying Liu; Xiao-Hui Zhang; Wei-Dong Mi; Ying-Lin Zhou; Chang-Sheng Zhang; Xin-Xiang Zhang
Journal:  Anal Bioanal Chem       Date:  2020-10-26       Impact factor: 4.142

3.  Selective and Accurate Determination Method of Propofol in Human Plasma by Mixed-Mode Cation Exchange Cartridge and GC-MS.

Authors:  Jae Sung Pyo
Journal:  J Anal Methods Chem       Date:  2016-08-11       Impact factor: 2.193

4.  Development of a highly sensitive gas chromatography-mass spectrometry method preceded by solid-phase microextraction for the analysis of propofol in low-volume cerebral microdialysate samples.

Authors:  Armin Sebastian Guntner; Simon Stöcklegger; Michael Kneidinger; Udo Illievich; Wolfgang Buchberger
Journal:  J Sep Sci       Date:  2019-01-30       Impact factor: 3.645

  4 in total

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