Literature DB >> 24154814

Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core.

Gerard Chun-Hao Liu1, Bryan Po-Wen Chen, Nancy Ting-Juan Ye, Chih-Hsien Wang, Wenlung Chen, Hsien-Ming Lee, Sunney I Chan, Joseph Jen-Tse Huang.   

Abstract

The amyloidogenic core in the TAR DNA-binding protein (TDP-43) C-terminal fragment has been characterized with its chemical, biochemical, and structural properties delineated. Various properties of the core sequence, including membrane impairment ability and the seeding effect, have also been studied.

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Year:  2013        PMID： 24154814     DOI： 10.1039/c3cc46762g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  The role of liquid-liquid phase separation in aggregation of the TDP-43 low-complexity domain.

Authors:  W Michael Babinchak; Raza Haider; Benjamin K Dumm; Prottusha Sarkar; Krystyna Surewicz; Jin-Kyu Choi; Witold K Surewicz
Journal:  J Biol Chem       Date:  2019-02-27       Impact factor: 5.157

2.  Tryptophan Probes of TDP-43 C-Terminal Domain Amyloid Formation.

Authors:  Sydney O Shuster; Jennifer C Lee
Journal:  J Phys Chem B       Date:  2021-04-09       Impact factor: 2.991

3.  Endocytosis regulates TDP-43 toxicity and turnover.

Authors:  Guangbo Liu; Alyssa N Coyne; Fen Pei; Spencer Vaughan; Matthew Chaung; Daniela C Zarnescu; J Ross Buchan
Journal:  Nat Commun       Date:  2017-12-12       Impact factor: 14.919

Review 4.  Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis.

Authors:  Archana Prasad; Vidhya Bharathi; Vishwanath Sivalingam; Amandeep Girdhar; Basant K Patel
Journal:  Front Mol Neurosci       Date:  2019-02-14       Impact factor: 5.639

5.  The influence of pathological mutations and proline substitutions in TDP-43 glycine-rich peptides on its amyloid properties and cellular toxicity.

Authors:  Chia-Sui Sun; Cindy Yu-Hsiang Wang; Bryan Po-Wen Chen; Ruei-Yu He; Gerard Chun-Hao Liu; Chih-Hsien Wang; Wenlung Chen; Yijuang Chern; Joseph Jen-Tse Huang
Journal:  PLoS One       Date:  2014-08-04       Impact factor: 3.240

6.  Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation.

Authors:  Miguel Mompeán; Avijit Chakrabartty; Emanuele Buratti; Douglas V Laurents
Journal:  PLoS Biol       Date:  2016-04-20       Impact factor: 8.029

7.  ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.

Authors:  Liangzhong Lim; Yuanyuan Wei; Yimei Lu; Jianxing Song
Journal:  PLoS Biol       Date:  2016-01-06       Impact factor: 8.029
  7 in total

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