Literature DB >> 2415392

Hormonal activation of single K+ channels via internal messenger in isolated pancreatic acinar cells.

K Suzuki, C C Petersen, O H Petersen.   

Abstract

The mechanism underlying hormonal activation of potassium channels was investigated in pig pancreatic acinar cells by patch-clamp single-channel and whole-cell current recordings. It was shown directly that a peptide hormone belonging to the cholecystokinin-gastrin family, CCK5, can activate single voltage-sensitive potassium channels which can be blocked by tetraethylammonium. The single-channel currents were recorded from electrically isolated cell-attached membrane patches to which the hormone had no access and the activation must therefore involve an intracellular messenger. The hormonal response requires external Ca2+ in the isolated membrane-patch area indicating that calcium gating is not directly linked to hormone-receptor interaction.

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Year:  1985        PMID： 2415392     DOI： 10.1016/0014-5793(85)80131-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Regulation of K+ channels in the basolateral membrane of Necturus oxyntic cells.

Authors:  S Ueda; D D Loo; G Sachs
Journal:  J Membr Biol       Date:  1987       Impact factor: 1.843

2.  Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells.

Authors:  L Changya; D V Gallacher; R F Irvine; B V Potter; O H Petersen
Journal:  J Membr Biol       Date:  1989-07       Impact factor: 1.843

3.  Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium.

Authors:  S P Soltoff; M K McMillian; L C Cantley; E J Cragoe; B R Talamo
Journal:  J Gen Physiol       Date:  1989-02       Impact factor: 4.086

4.  External ATP triggers a biphasic activation process of a calcium-dependent K+ channel in cultured bovine aortic endothelial cells.

Authors:  R Sauve; L Parent; C Simoneau; G Roy
Journal:  Pflugers Arch       Date:  1988-10       Impact factor: 3.657

5.  Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol.

Authors:  S P Soltoff; M K McMillian; E J Cragoe; L C Cantley; B R Talamo
Journal:  J Gen Physiol       Date:  1990-02       Impact factor: 4.086

6.  Patch-clamp studies of K+ and Cl- channel currents in canine pancreatic acinar cells.

Authors:  K Suzuki; K Onoe
Journal:  Pflugers Arch       Date:  1991-03       Impact factor: 3.657

7.  The ACh-induced whole-cell currents in sheep parotid secretory cells. Do BK channels really carry the ACh-evoked whole-cell K+ current?

Authors:  T Hayashi; C Hirono; J A Young; D I Cook
Journal:  J Membr Biol       Date:  1995-03       Impact factor: 1.843

8.  K+ efflux from the monkey eccrine secretory coil during the transient of stimulation with agonists.

Authors:  K Saga; F Sato; K Sato
Journal:  J Physiol       Date:  1988-11       Impact factor: 5.182

Review 9.  Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma.

Authors:  Julie Schnipper; Isabelle Dhennin-Duthille; Ahmed Ahidouch; Halima Ouadid-Ahidouch
Journal:  Front Pharmacol       Date:  2020-10-16       Impact factor: 5.810
  9 in total

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