Literature DB >> 2415371

Calcitonin gene-related peptide is a potent inhibitor of substance P degradation.

P Le Greves, F Nyberg, L Terenius, T Hökfelt.   

Abstract

Calcitonin gene-related peptide (CGRP) was found to potently inhibit a substance P endopeptidase isolated from human CSF. CGRP potentiated substance P irritant actions; a possible mechanism is interaction for a common metabolic step. Somatostatin is another peptide capable of competing with substance P endopeptidase.

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Year:  1985        PMID： 2415371     DOI： 10.1016/0014-2999(85)90706-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  35 in total

1.  Blockade and reversal of spinal morphine tolerance by peptide and non-peptide calcitonin gene-related peptide receptor antagonists.

Authors:  K J Powell; W Ma; M Sutak; H Doods; R Quirion; K Jhamandas
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

Review 2.  Spinal-Cord plasticity: independent and interactive effects of neuromodulator and activity-dependent plasticity.

Authors:  D Parker
Journal:  Mol Neurobiol       Date:  2000 Aug-Dec       Impact factor: 5.590

Review 3.  Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome.

Authors:  Bin Feng; Jun Ho La; Erica S Schwartz; G F Gebhart
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2012-03-08       Impact factor: 4.052

4.  Utilizing molecular details of the pain system to illustrate biochemical principles.

Authors:  Robert Boal; Richard G Gillette; William H Borman
Journal:  J Chiropr Educ       Date:  2010

5.  The effects of calcitonin gene-related peptide on submucosal gland secretion and epithelial albumin transport in the ferret trachea in vitro.

Authors:  S E Webber; J C Lim; J G Widdicombe
Journal:  Br J Pharmacol       Date:  1991-01       Impact factor: 8.739

6.  Ultrastructural studies on calcitonin gene-related peptide-, tachykinins- and somatostatin-immunoreactive neurones in rat dorsal root ganglia: evidence for the colocalization of different peptides in single secretory granules.

Authors:  A Merighi; J M Polak; S J Gibson; S Gulbenkian; K L Valentino; S M Peirone
Journal:  Cell Tissue Res       Date:  1988-10       Impact factor: 5.249

7.  Calcitonin gene-related peptide desensitizes skeletal muscle arterioles to substance P in vivo.

Authors:  A Ohlén; N P Wiklund; M G Persson; P Hedqvist
Journal:  Br J Pharmacol       Date:  1988-11       Impact factor: 8.739

8.  Peptidergic modulation of synaptic transmission in the parabrachial nucleus in vitro: importance of degradative enzymes in regulating synaptic efficacy.

Authors:  T M Saleh; S B Kombian; J A Zidichouski; Q J Pittman
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167

9.  Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors.

Authors:  H Liu; J L Brown; L Jasmin; J E Maggio; S R Vigna; P W Mantyh; A I Basbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

10.  Intrathecal CGRP8-37-induced bilateral increase in hindpaw withdrawal latency in rats with unilateral inflammation.

Authors:  L C Yu; P Hansson; G Brodda-Jansen; E Theodorsson; T Lundeberg
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739
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