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Literature DB >> 2415352

Demonstration of immunochemical identity between the nerve growth factor-inducible large external (NILE) glycoprotein and the cell adhesion molecule L1.

E Bock, C Richter-Landsberg, A Faissner, M Schachner.

Abstract

The nerve growth factor-inducible large external (NILE) glycoprotein and the neural cell adhesion molecule L1 were shown to be immunochemically identical. Immunoprecipitation with L1 and NILE antibodies of [3H]fucose-labeled material from culture supernatants and detergent extracts of NGF-treated rat PC12 pheochromocytoma cells yielded comigrating bands by SDS-PAGE. NILE antibodies reacted with immunopurified L1 antigen, but not with N-CAM and other L2 epitope-bearing glycoproteins from adult mouse brain. Finally, by sequential immunoprecipitation from detergent extracts of [35S]methionine-labeled early post-natal cerebellar cell cultures or [3H]fucose-labeled NGF-treated PC12 cells, all immunoreactivity for NILE antibody could be removed by pre-clearing with L1 antibody and vice versa.

Entities: Chemical

Mesh：

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Year: 1985 PMID： 2415352 PMCID： PMC554576 DOI： 10.1002/j.1460-2075.1985.tb04001.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

36 in total

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Authors: J C McGuire; L A Greene; A V Furano
Journal: Cell Date: 1978-10 Impact factor: 41.582

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Authors: M Grumet; U Rutishauser; G M Edelman
Journal: Nature Date: 1982-02-25 Impact factor: 49.962

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Journal: J Neurosci Date: 1983-01 Impact factor: 6.167

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Authors: J P Thiery; J L Duband; U Rutishauser; G M Edelman
Journal: Proc Natl Acad Sci U S A Date: 1982-11 Impact factor: 11.205

5. Purification of the synaptic membrane glycoprotein D2 from rat brain.

Authors: S Rasmussen; J Ramlau; N H Axelsen; E Bock
Journal: Scand J Immunol Date: 1982-02 Impact factor: 3.487

6. Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies.

Authors: G Keilhauer; A Faissner; M Schachner
Journal: Nature Date: 1985 Aug 22-28 Impact factor: 49.962

7. Identification of neural and adrenal medullary surface membrane glycoproteins recognized by antisera to cultured rat sympathetic neurons and PC12 pheochromocytoma cells.

Authors: V M Lee; L Greene; M L Shelanski
Journal: Neuroscience Date: 1981 Impact factor: 3.590

8. Expression of Thy-1, H-2, and NS-4 cell surface antigens and tetanus toxin receptors in early postnatal and adult mouse cerebellum.

Authors: J Schnitzer; M Schachner
Journal: J Neuroimmunol Date: 1981-12 Impact factor: 3.478

9. Effects of fasciculation on the outgrowth of neurites from spinal ganglia in culture.

Authors: U Rutishauser; G M Edelman
Journal: J Cell Biol Date: 1980-11 Impact factor: 10.539

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Authors: U Rutishauser; J P Thiery; R Brackenbury; G M Edelman
Journal: J Cell Biol Date: 1978-11 Impact factor: 10.539

29 in total

1. The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions.

Authors: G Kadmon; A Kowitz; P Altevogt; M Schachner
Journal: J Cell Biol Date: 1990-01 Impact factor: 10.539

2. The Arg-Gly-Asp motif in the cell adhesion molecule L1 promotes neurite outgrowth via interaction with the alphavbeta3 integrin.

Authors: P M Yip; X Zhao; A M Montgomery; C H Siu
Journal: Mol Biol Cell Date: 1998-02 Impact factor: 4.138

3. Immunocytological characterization of the expression of cell adhesion molecule L1 during early innervation of mouse otocysts.

Authors: J P Mbiene; C J Dechesne; M Schachner; A Sans
Journal: Cell Tissue Res Date: 1989-01 Impact factor: 5.249

4. An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.

Authors: C Lagenaur; V Lemmon
Journal: Proc Natl Acad Sci U S A Date: 1987-11 Impact factor: 11.205

5. Variants of human L1 cell adhesion molecule arise through alternate splicing of RNA.

Authors: R A Reid; J J Hemperly
Journal: J Mol Neurosci Date: 1992 Impact factor: 3.444

6. Immunolocalization of the neural cell adhesion molecule L1 in non-proliferating epithelial cells of the male urogenital tract.

Authors: R Kujat; F Miragall; D Krause; R Dermietzel; K H Wrobel
Journal: Histochem Cell Biol Date: 1995-04 Impact factor: 4.304

10. Phosphatidylinositol is involved in the membrane attachment of NCAM-120, the smallest component of the neural cell adhesion molecule.

Authors: H T He; J Barbet; J C Chaix; C Goridis
Journal: EMBO J Date: 1986-10 Impact factor: 11.598