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Literature DB >> 24151321

Immune activation and the role of TLRs and TLR agonists in the pathogenesis of HIV-1 infection in the humanized mouse model.

Abstract

Immune activation plays a critical role in HIV-1 pathogenesis, but the pathways that are responsible for HIV-1-associated immune activation are not well understood. Recent advances in the development of a humanized mouse model for HIV-1 infection might provide new approaches to study the mechanisms of HIV-1 associated immune activation, and to test interventions aimed at reducing HIV-1 pathogenesis.

Entities: Disease Species

Keywords: HIV-1; TLR; humanized mouse; innate immunity; pathogenesis

Mesh：

Substances：
Toll-Like Receptors

Year: 2013 PMID： 24151321 PMCID： PMC3807976 DOI： 10.1093/infdis/jit402

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

50 in total

1. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment.

Authors: Karl-Dimiter Bissig; Stefan F Wieland; Phu Tran; Masanori Isogawa; Tam T Le; Francis V Chisari; Inder M Verma
Journal: J Clin Invest Date: 2010-02-22 Impact factor: 14.808

2. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection.

Authors: Wei Jiang; Michael M Lederman; Peter Hunt; Scott F Sieg; Kathryn Haley; Benigno Rodriguez; Alan Landay; Jeffrey Martin; Elizabeth Sinclair; Ava I Asher; Steven G Deeks; Daniel C Douek; Jason M Brenchley
Journal: J Infect Dis Date: 2009-04-15 Impact factor: 5.226

3. Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques.

Authors: Levelle D Harris; Brian Tabb; Donald L Sodora; Mirko Paiardini; Nichole R Klatt; Daniel C Douek; Guido Silvestri; Michaela Müller-Trutwin; Ivona Vasile-Pandrea; Cristian Apetrei; Vanessa Hirsch; Jeffrey Lifson; Jason M Brenchley; Jacob D Estes
Journal: J Virol Date: 2010-05-19 Impact factor: 5.103

4. Exposure to HIV-1-encoded Toll-like receptor 8 ligands enhances monocyte response to microbial encoded Toll-like receptor 2/4 ligands.

Authors: Marianne W Mureith; J Judy Chang; Jeffrey D Lifson; Thumbi Ndung'u; Marcus Altfeld
Journal: AIDS Date: 2010-07-31 Impact factor: 4.177

Review 5. Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.

Authors: Donald L Sodora; Jonathan S Allan; Cristian Apetrei; Jason M Brenchley; Daniel C Douek; James G Else; Jacob D Estes; Beatrice H Hahn; Vanessa M Hirsch; Amitinder Kaur; Frank Kirchhoff; Michaela Muller-Trutwin; Ivona Pandrea; Jörn E Schmitz; Guido Silvestri
Journal: Nat Med Date: 2009-08 Impact factor: 53.440

6. Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.

Authors: Angela Meier; J Judy Chang; Ellen S Chan; Richard B Pollard; Harlyn K Sidhu; Smita Kulkarni; Tom Fang Wen; Robert J Lindsay; Liliana Orellana; Donna Mildvan; Suzane Bazner; Hendrik Streeck; Galit Alter; Jeffrey D Lifson; Mary Carrington; Ronald J Bosch; Gregory K Robbins; Marcus Altfeld
Journal: Nat Med Date: 2009-07-13 Impact factor: 53.440

7. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys.

Authors: Steven E Bosinger; Qingsheng Li; Shari N Gordon; Nichole R Klatt; Lijie Duan; Luoling Xu; Nicholas Francella; Abubaker Sidahmed; Anthony J Smith; Elizabeth M Cramer; Ming Zeng; David Masopust; John V Carlis; Longsi Ran; Thomas H Vanderford; Mirko Paiardini; R Benjamin Isett; Don A Baldwin; James G Else; Silvija I Staprans; Guido Silvestri; Ashley T Haase; David J Kelvin
Journal: J Clin Invest Date: 2009-12 Impact factor: 14.808

8. Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation.

Authors: Jeffrey A Martinson; Carlos J Montoya; Xiomara Usuga; Rollie Ronquillo; Alan L Landay; Seema N Desai
Journal: Antimicrob Agents Chemother Date: 2009-11-30 Impact factor: 5.191

9. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy.

Authors: Peter W Hunt; Jeffrey N Martin; Elizabeth Sinclair; Barry Bredt; Elilta Hagos; Harry Lampiris; Steven G Deeks
Journal: J Infect Dis Date: 2003-04-23 Impact factor: 5.226

10. High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment.

Authors: Veronica D Gonzalez; Karolin Falconer; Kim G Blom; Olle Reichard; Birgitte Mørn; Alex Lund Laursen; Nina Weis; Annette Alaeus; Johan K Sandberg
Journal: J Virol Date: 2009-08-26 Impact factor: 5.103

4 in total