Literature DB >> 24151098

A new enantioselective synthesis of the anticonvulsant drug pregabalin (Lyrica) based on a hydrolytic kinetic resolution method.

Mohammad Mujahid1, Murugan Muthukrishnan.   

Abstract

A practical and efficient enantioselective synthesis of the anticonvulsant drug pregabalin is described for the first time using Jacobsen's hydrolytic kinetic resolution of a terminal epoxide as a key step and a source of chirality.
© 2013 Wiley Periodicals, Inc.

Entities:  

Keywords:  anticonvulsant drug; hydrolytic kinetic resolution; pregabalin

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Year:  2013        PMID： 24151098     DOI： 10.1002/chir.22253

Source DB:  PubMed          Journal:  Chirality        ISSN： 0899-0042            Impact factor:   2.437


  2 in total

1.  Enantioselective C(sp3)-C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis.

Authors:  Srikrishna Bera; Runze Mao; Xile Hu
Journal:  Nat Chem       Date:  2020-12-30       Impact factor: 24.427

2.  Carboxylic acids as a traceless activation group for conjugate additions: a three-step synthesis of (±)-pregabalin.

Authors:  Lingling Chu; Chisa Ohta; Zhiwei Zuo; David W C MacMillan
Journal:  J Am Chem Soc       Date:  2014-07-28       Impact factor: 15.419
  2 in total

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