Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Amino- and carboxyl-terminal sequence of Moloney murine leukemia virus reverse transcriptase.

Literature DB >> 2414914

Amino- and carboxyl-terminal sequence of Moloney murine leukemia virus reverse transcriptase.

T D Copeland, G F Gerard, C W Hixson, S Oroszlan.

Abstract

The NH2-terminal amino acid sequence of Moloney murine leukemia virus reverse transcriptase was determined to be Thr-Leu-Asn-Ile-Glu-Asp-Glu-Tyr-Arg-Leu-His-Glu-. The comparison of the amino acid analysis data obtained after carboxypeptidase Y digestion with the published nucleotide sequence (T. M. Shinnick, R. A. Lerner, and J. G. Sutcliffe, Nature (London) 293, 543-548, 1981) led to the conclusion that the COOH-terminus is Leu coded by CTC in nucleotide positions 4608-4610, and the tentative COOH-terminal sequence is Pro-Asp-Thr-Ser-Thr-Leu-Leu-OH. In light of these and previously reported results the complexity and map order of the pol gene are discussed.

Entities: Chemical Species

Mesh：

Substances：

Year: 1985 PMID： 2414914 DOI： 10.1016/0042-6822(85)90411-8

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

Keyword Cloud
Cited

11 in total

1. Defects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase H.

Authors: A Telesnitsky; S W Blain; S P Goff
Journal: J Virol Date: 1992-02 Impact factor: 5.103

2. Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro.

Authors: A Engelman; R Craigie
Journal: J Virol Date: 1992-11 Impact factor: 5.103

3. Strong sequence conservation among horizontally transmissible, minimally pathogenic feline leukemia viruses.

Authors: P R Donahue; E A Hoover; G A Beltz; N Riedel; V M Hirsch; J Overbaugh; J I Mullins
Journal: J Virol Date: 1988-03 Impact factor: 5.103

4. Murine leukemia virus pol gene products: analysis with antisera generated against reverse transcriptase and endonuclease fusion proteins expressed in Escherichia coli.

Authors: S C Hu; D L Court; M Zweig; J G Levin
Journal: J Virol Date: 1986-10 Impact factor: 5.103

10. Sulphydryl groups in the template-primer-binding domain of murine leukaemia virus reverse transcriptase. Identification and functional analysis of cysteine-90.

Authors: S Basu; A Basu; M J Modak
Journal: Biochem J Date: 1993-12-15 Impact factor: 3.857

Amino- and carboxyl-terminal sequence of Moloney murine leukemia virus reverse transcriptase.

1. Defects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase H.

2. Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro.

3. Strong sequence conservation among horizontally transmissible, minimally pathogenic feline leukemia viruses.

4. Murine leukemia virus pol gene products: analysis with antisera generated against reverse transcriptase and endonuclease fusion proteins expressed in Escherichia coli.

5. Analysis of retroviral pol gene products with antisera raised against fusion proteins produced in Escherichia coli.

6. Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert.

7. Analysis of mutant Moloney murine leukemia viruses containing linker insertion mutations in the 3' region of pol.

8. Sequence-specific binding of DNA by the Moloney murine leukemia virus integrase protein.

9. Characterization of the protease of a fish retrovirus, walleye dermal sarcoma virus.

10. Sulphydryl groups in the template-primer-binding domain of murine leukaemia virus reverse transcriptase. Identification and functional analysis of cysteine-90.