AIMS: A variable proportion, up to 30%, of patients who undergo cardiac resynchronization therapy (CRT) do not benefit from treatment. The aim of the Cardiac Resynchronization Therapy MOdular REgistry (CRT MORE) is to determine whether specific electrocardiographic and radiographic parameters can be used to predict clinical and echocardiographic response to CRT. METHODS: The CRT MORE is a prospective, single-arm, multicenter cohort study designed to evaluate the electrocardiographic and radiographic predictors of response to CRT. All study patients receive a pacemaker or implantable defibrillator for CRT delivery in accordance with current guidelines. Enrollment started in December 2011 and is scheduled to end in November 2013. Approximately 1100 consecutive patients will be enrolled in 30 Italian centers and will be followed up for 60 months after implantation. The primary endpoint is the improvement in clinical (Clinical Composite Score) and echocardiographic (a decrease of ≥ 15% in left ventricular end-systolic volume) parameters at the 6-month follow-up visit. CONCLUSION: This study might provide important information about which electrocardiographic and radiographic parameters better predict CRT response.
AIMS: A variable proportion, up to 30%, of patients who undergo cardiac resynchronization therapy (CRT) do not benefit from treatment. The aim of the Cardiac Resynchronization Therapy MOdular REgistry (CRT MORE) is to determine whether specific electrocardiographic and radiographic parameters can be used to predict clinical and echocardiographic response to CRT. METHODS: The CRT MORE is a prospective, single-arm, multicenter cohort study designed to evaluate the electrocardiographic and radiographic predictors of response to CRT. All study patients receive a pacemaker or implantable defibrillator for CRT delivery in accordance with current guidelines. Enrollment started in December 2011 and is scheduled to end in November 2013. Approximately 1100 consecutive patients will be enrolled in 30 Italian centers and will be followed up for 60 months after implantation. The primary endpoint is the improvement in clinical (Clinical Composite Score) and echocardiographic (a decrease of ≥ 15% in left ventricular end-systolic volume) parameters at the 6-month follow-up visit. CONCLUSION: This study might provide important information about which electrocardiographic and radiographic parameters better predict CRT response.
Authors: Antonio D'Onofrio; Salvatore Ivan Caico; Assunta Iuliano; Paolo Pieragnoli; Valter Bianchi; Daniela Orsida; Antonio Pani; Mario Pasqualini; Francesca Amadori; Ludovico Vasquez; Antonello Talarico; Chiara Minoia; Roberto Ospizio; Greta Merlotti; Maurizio Malacrida; Giuseppe Stabile Journal: J Interv Card Electrophysiol Date: 2018-03-03 Impact factor: 1.900
Authors: Emanuele Bertaglia; Giuseppe Arena; Domenico Pecora; Albino Reggiani; Antonio D'Onofrio; Pietro Palmisano; Antonio De Simone; Salvatore I Caico; Massimiliano Marini; Giampiero Maglia; Anna Ferraro; Francesco Solimene; Antonella Cecchetto; Maurizio Malacrida; Giovanni L Botto; Maurizio Lunati; Giuseppe Stabile Journal: Clin Cardiol Date: 2019-07-13 Impact factor: 2.882