Literature DB >> 24148834

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.

Richard K Amewu1, James Chadwick, Afthab Hussain, Somnath Panda, Rinki Rinki, Omar Janneh, Stephen A Ward, Candel Miguel, Hollie Burrell-Saward, Livia Vivas, Paul M O'Neill.   

Abstract

The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC(50)s versus colon (HT29-AK and leukemia (HL60) cell lines.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Apoptosis; Leukaemia; Malaria

Mesh：

Substances：

Year:  2013        PMID： 24148834     DOI： 10.1016/j.bmc.2013.09.047

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether.

Authors:  Ryan C Conyers; Jennifer R Mazzone; Maxime A Siegler; Abhai K Tripathi; David J Sullivan; Bryan T Mott; Gary H Posner
Journal:  Bioorg Med Chem Lett       Date:  2014-01-30       Impact factor: 2.823

Review 2.  Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold.

Authors:  Mithun Rudrapal; Dipak Chetia
Journal:  Drug Des Devel Ther       Date:  2016-11-01       Impact factor: 4.162

3.  Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide-Pyrazole Hybrids.

Authors:  Patrícia S M Amado; Inês C C Costa; José A Paixão; Ricardo F Mendes; Sofia Cortes; Maria L S Cristiano
Journal:  Molecules       Date:  2022-08-24       Impact factor: 4.927
  3 in total

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