Literature DB >> 2414776

Monoclonal antibody that defines human myoepithelium.

S H Dairkee, C Blayney, H S Smith, A J Hackett.   

Abstract

We have isolated a mouse monoclonal antibody that, upon immunohistochemical localization in frozen sections, displays specificity for human myoepithelial cells in the resting mammary gland, sweat glands, and salivary glands. Furthermore, this antibody was strongly and homogeneously reactive with frozen sections of 3 of 60 breast carcinoma specimens. Using immunolocalization techniques in conjunction with polyacrylamide gel electrophoresis, we have determined that the reactivity of this monoclonal antibody is directed toward a 51,000-dalton keratin polypeptide. The potential uses of this antibody in the prognosis of human mammary carcinoma and in understanding the role of the myoepithelium in development and differentiation are discussed.

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Year:  1985        PMID： 2414776      PMCID： PMC391354          DOI： 10.1073/pnas.82.21.7409

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

2.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

Review 3.  Patterns of gene expression and the cellular origins of human leukaemias.

Authors:  M Greaves; G Janossy
Journal:  Biochim Biophys Acta       Date:  1978-10-27

4.  The myoepithelium in human breast carcinoma.

Authors:  A Ahmed
Journal:  J Pathol       Date:  1974-06       Impact factor: 7.996

5.  Differentiation of the myoepithelial cells of the rat submandibular gland in vivo and in vitro: an ultrastructural study.

Authors:  L S Cutler; A P Chaudhry
Journal:  J Morphol       Date:  1973-07       Impact factor: 1.804

6.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

Review 7.  Cytology of the secretion in mammalian sweat glands.

Authors:  K Kurosumi; S Shibasaki; T Ito
Journal:  Int Rev Cytol       Date:  1984

8.  Contractile proteins in human cancer cells. Immunofluorescent and electron microscopic study.

Authors:  G Gabbiani; J Csank-Brassert; J C Schneeberger; Y Kapanci; P Trenchev; E J Holborow
Journal:  Am J Pathol       Date:  1976-06       Impact factor: 4.307

9.  Identification of myosin in human epithelial cancers with immunofluorescence.

Authors:  J C Macartney; M A Trevithick; L Kricka; R C Curran
Journal:  Lab Invest       Date:  1979-11       Impact factor: 5.662

10.  Intermediate-sized filaments of the prekeratin type in myoepithelial cells.

Authors:  W W Franke; E Schmid; C Freudenstein; B Appelhans; M Osborn; K Weber; T W Keenan
Journal:  J Cell Biol       Date:  1980-03       Impact factor: 10.539
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  27 in total

Review 1.  Stem cells in the human breast.

Authors:  Ole William Petersen; Kornelia Polyak
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-05       Impact factor: 10.005

2.  Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

Authors:  O W Petersen; L Rønnov-Jessen; A R Howlett; M J Bissell
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

3.  S-100 protein antibodies do not label normal salivary gland myoepithelium. Histogenetic implications for salivary gland tumors.

Authors:  I Dardick; M Stratis; W R Parks; F G DeNardi; H J Kahn
Journal:  Am J Pathol       Date:  1991-03       Impact factor: 4.307

Review 4.  AACR centennial series: the biology of cancer metastasis: historical perspective.

Authors:  James E Talmadge; Isaiah J Fidler
Journal:  Cancer Res       Date:  2010-07-07       Impact factor: 12.701

5.  Basal epithelial cells of human prostate gland are not myoepithelial cells. A comparative immunohistochemical and ultrastructural study with the human salivary gland.

Authors:  J R Srigley; I Dardick; R W Hartwick; L Klotz
Journal:  Am J Pathol       Date:  1990-04       Impact factor: 4.307

6.  The cells of the dorsal iris involved in lens regeneration are myoepithelial cells whose cytoskeleton changes during cell type conversion.

Authors:  Y Yang; S E Zalik
Journal:  Anat Embryol (Berl)       Date:  1994-06

7.  Cytokeratin profile of immunomagnetically separated epithelial subsets of the human mammary gland.

Authors:  S Dairkee; H W Heid
Journal:  In Vitro Cell Dev Biol Anim       Date:  1993-05       Impact factor: 2.416

Review 8.  Myoepithelial Cells (MEC) of the Salivary Glands in Health and Tumours.

Authors:  Ravi Teja Chitturi; V Veeravarmal; R Madhavan Nirmal; B Venkat Ramana Reddy
Journal:  J Clin Diagn Res       Date:  2015-03-01

9.  Immunolocalization of a human basal epithelium specific keratin in benign and malignant breast disease.

Authors:  S H Dairkee; B M Ljung; H Smith; A Hackett
Journal:  Breast Cancer Res Treat       Date:  1987-10       Impact factor: 4.872

10.  Keratin profiles in normal/hyperplastic prostates and prostate carcinoma.

Authors:  H Okada; A Tsubura; A Okamura; H Senzaki; Y Naka; Y Komatz; S Morii
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992
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