OBJECTIVE: To quantitatively determine the bisphenol-A (BPA) leached from orthodontic materials during simulated intraoral exposure. MATERIALS AND METHODS: Samples of orthodontic materials were subjected to simulated abrasion, immersion in artificial saliva, thermal shock via temperature cycling, and simulated intraoral exposure. Sample aliquots were collected for up to 2 weeks after artificial saliva immersion, derivatized, then analyzed for BPA by gas chromatography/mass spectroscopy. RESULTS: Quantifiable amounts of leached BPA were observed from a thermoformed orthodontic retainer material (7.63 µg/g of material) and an orthodontic adhesive (2.75 µg/g of material). BPA leaching was only observed within the first 3 days of artificial saliva immersion. CONCLUSIONS: Under the test conditions, BPA was observed to leach from two orthodontic materials. While the quantities of leached BPA were below the reference dose for daily intake, existing data of low-dose effects and medical disorders associated with elevated urinary BPA levels suggest that BPA exposure, and thus the use of the leaching materials identified in this study, should be reduced or eliminated.
OBJECTIVE: To quantitatively determine the bisphenol-A (BPA) leached from orthodontic materials during simulated intraoral exposure. MATERIALS AND METHODS: Samples of orthodontic materials were subjected to simulated abrasion, immersion in artificial saliva, thermal shock via temperature cycling, and simulated intraoral exposure. Sample aliquots were collected for up to 2 weeks after artificial saliva immersion, derivatized, then analyzed for BPA by gas chromatography/mass spectroscopy. RESULTS: Quantifiable amounts of leached BPA were observed from a thermoformed orthodontic retainer material (7.63 µg/g of material) and an orthodontic adhesive (2.75 µg/g of material). BPA leaching was only observed within the first 3 days of artificial saliva immersion. CONCLUSIONS: Under the test conditions, BPA was observed to leach from two orthodontic materials. While the quantities of leached BPA were below the reference dose for daily intake, existing data of low-dose effects and medical disorders associated with elevated urinary BPA levels suggest that BPA exposure, and thus the use of the leaching materials identified in this study, should be reduced or eliminated.
Authors: Barry G Timms; Kembra L Howdeshell; Lesley Barton; Sarahann Bradley; Catherine A Richter; Frederick S vom Saal Journal: Proc Natl Acad Sci U S A Date: 2005-05-02 Impact factor: 11.205
Authors: Sergi Soriano; Paloma Alonso-Magdalena; Marta García-Arévalo; Anna Novials; Sarheed J Muhammed; Albert Salehi; Jan-Ake Gustafsson; Ivan Quesada; Angel Nadal Journal: PLoS One Date: 2012-02-08 Impact factor: 3.240
Authors: Min Kyong Moon; Min Joo Kim; In Kyung Jung; Young Do Koo; Hwa Young Ann; Kwan Jae Lee; Soon Hee Kim; Yeo Cho Yoon; Bong-Jun Cho; Kyong Soo Park; Hak C Jang; Young Joo Park Journal: J Korean Med Sci Date: 2012-05-26 Impact factor: 2.153
Authors: Paloma Alonso-Magdalena; Ouahiba Laribi; Ana B Ropero; Esther Fuentes; Cristina Ripoll; Bernat Soria; Angel Nadal Journal: Environ Health Perspect Date: 2005-08 Impact factor: 9.031
Authors: Antonia M Calafat; Xiaoyun Ye; Lee-Yang Wong; John A Reidy; Larry L Needham Journal: Environ Health Perspect Date: 2008-01 Impact factor: 9.031
Authors: Karla C Horta; Guido A Marañón-Vásquez; Mírian A N Matsumoto; Marília R Moreira; Fábio L Romano; Alberto Consolaro; Israel D de Souza; Tamires A V Brigante; Maria E C Queiroz; Paulo Nelson-Filho; Erika C Küchler Journal: Prog Orthod Date: 2018-07-02 Impact factor: 2.750