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Literature DB >> 24146472

Antioxidative potential of Duranta repens (Linn.) fruits against H2O2 induced cell death in vitro.

Md Asaduzzaman Khan¹, Mohammad Mijanur Rahman, Mousumi Tania, Nusrat Fatima Shoshee, Ai-hua Xu, Han-chun Chen.

Abstract

The effects of Duranta repens fruits were investigated on H2O2 induced oxidative cell death to evaluate its antioxidative potential in vitro. HEK293T cells were treated with different concentrations [0-1000 µg/ ml] of ethanol extract (E-Ex) and methanol extract (M-Ex) of D. repens for 24h, and then treated with 100 µM H2O2 for 24h. Cell viability, antioxidant parameters of cells, and antioxidant constituents of the extracts were determined. Treatment with limited dose of E-Ex or M-Ex increased the survival rate of H2O2-treated HEK293T cells, however the extra-high dose showed growth inhibitory effect. Treatment with E-Ex or M-Ex protected cellular lipid per-oxidation. In vitro analyses showed the 2,2-diphenyl-1-picrylhydrazyl and H2O2 scavenging activities as well as reducing potential of the extracts. We report here that the limited dose of E-Ex and M-Ex possess antioxidative potential, which can protect H2O2-induced oxidative cell damage.

Entities: Chemical Species

Keywords: Antioxidant; Duranta repens (Linn.); Lipid per-oxidation; Oxidative cell death; Phytochemicals

Mesh：

Substances：

Year: 2013 PMID： 24146472 PMCID： PMC3777584

Source DB: PubMed Journal: Afr J Tradit Complement Altern Med ISSN： 2505-0044

18 in total

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Authors: B Sun; M Fukuhara
Journal: Toxicology Date: 1997-09-26 Impact factor: 4.221

2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors: M M Bradford
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

2. The effect of Malus doumeri leaf flavonoids on oxidative stress injury induced by hydrogen peroxide (H₂O₂) in human embryonic kidney 293 T cells.

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2 in total

Antioxidative potential of Duranta repens (Linn.) fruits against H2O2 induced cell death in vitro.

1. Effects of co-administration of butylated hydroxytoluene, butylated hydroxyanisole and flavonoids on the activation of mutagens and drug-metabolizing enzymes in mice.

2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

3. Antioxidant activity of flavonoids from Licania licaniaeflora.

4. Antiproliferative constituents in the plants 7. Leaves of Clerodendron bungei and leaves and bark of C. trichotomum.

Review 5. Oxygen toxicity, oxygen radicals, transition metals and disease.

6. Antioxidative iridoid glycosides from the sky flower (Duranta repens Linn).

7. Protective effect of alpha-keto acids on the oxidative hemolysis.

Review 8. [Free radicals and antioxidants: human physiology, pathology and therapeutic aspects].

9. Enzyme inhibitory constituents from Duranta repens.

Review 10. Oxidative stress: the paradox of aerobic life.

1. An Updated Review on Phytochemical Properties of "Golden Dewdrop" Duranta erecta.

2. The effect of Malus doumeri leaf flavonoids on oxidative stress injury induced by hydrogen peroxide (H₂O₂) in human embryonic kidney 293 T cells.