Yuju Zheng1, Ye Fang, Shaojin Li, Bangxi Zheng. 1. Department of Cardiothoracic Surgery, Shantou Chaonan Mingsheng Hospital; First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China. E-mail: zhengyuju@163.com.
Abstract
OBJECTIVE: To detect serum content of cofilin protein in patients with lung cancer and investigate its clinical value. METHODS: The serum content of cofilin protein was detected in 30 cases of lung cancer and 30 healthy control subjects using enzyme-linked immunosorbent assay. RESULTS: The mean serum content of cofilin protein was 0.485∓0.465 ng/ml in patients with lung cancer and 0.203∓0.102 ng/ml in the control subjects, showing a significant difference between them (P<0.05). The content of cofilin protein in patients with stage III and IV lung cancer 0.744∓0.584 ng/ml, significantly higher than that in stage II patients (0.257∓0.126 ng/ml). CONCLUSION: Serum cofilin protein is elevated in patients with lung cancer, especially in cases in advanced stages, suggesting its relation with lung cancer staging.
OBJECTIVE: To detect serum content of cofilin protein in patients with lung cancer and investigate its clinical value. METHODS: The serum content of cofilin protein was detected in 30 cases of lung cancer and 30 healthy control subjects using enzyme-linked immunosorbent assay. RESULTS: The mean serum content of cofilin protein was 0.485∓0.465 ng/ml in patients with lung cancer and 0.203∓0.102 ng/ml in the control subjects, showing a significant difference between them (P<0.05). The content of cofilin protein in patients with stage III and IV lung cancer 0.744∓0.584 ng/ml, significantly higher than that in stage II patients (0.257∓0.126 ng/ml). CONCLUSION: Serum cofilin protein is elevated in patients with lung cancer, especially in cases in advanced stages, suggesting its relation with lung cancer staging.
Authors: M P Rangel; L Antonangelo; M M P Acencio; C S Faria; V K de Sá; P S Leão; C Farhat; A T Fabro; A Longatto Filho; R M Reis; T Takagaki; V L Capelozzi Journal: Braz J Med Biol Res Date: 2018-05-28 Impact factor: 2.590