Koji Tanaka1, Toshiyuki Uehara2, Kazumi Kimura3, Yasushi Okada4, Yasuhiro Hasegawa5, Norio Tanahashi6, Akifumi Suzuki7, Shigeharu Takagi8, Jyoji Nakagawara9, Kazumasa Arii10, Shinji Nagahiro11, Kuniaki Ogasawara12, Takehiko Nagao13, Shinichiro Uchiyama13, Masayasu Matsumoto14, Koji Iihara15, Kazunori Toyoda1, Kazuo Minematsu1. 1. Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan. 2. Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address: tuehara@ncvc.go.jp. 3. Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Japan. 4. Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan. 5. Department of Neurology, Nagoya Daini Red Cross Hospital, Nagoya, Japan. 6. Department of Neurology and Cerebrovascular Medicine, Saitama Medical University, Saitama International Medical Center, Hidaka, Japan. 7. Department of Stroke Science, Research Institute for Brain and Blood Vessels Akita, Akita, Japan. 8. Department of Neurology, Tokai University Hospital, Isehara, Japan. 9. Department of Neurosurgery, Nakamura Memorial Hospital, Sapporo, Japan. 10. Department of Neurology, Ebara Hospital, Tokyo, Japan. 11. Department of Neurosurgery, Tokushima University Hospital, Tokushima, Japan. 12. Department of Neurosurgery, Iwate Medical University Hospital, Morioka, Japan. 13. Department of Neurology, Tokyo Women's Medical University Hospital, Tokyo, Japan. 14. Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, Japan. 15. Department of Neurosurgery, National Cerebral and Cardiovascular Center, Suita, Japan.
Abstract
BACKGROUND: Transient monocular blindness (TMB) is associated with a transient ischemic attack (TIA). The purpose of this study was to investigate the features of TMB in the Japanese population using data from a multicenter retrospective study of TIA. METHODS: The subjects were consecutive TIA patients admitted to 13 stroke centers within 7 days after symptom onset. We compared clinical characteristics of patients with TMB and those without TMB who had other symptoms of cerebral TIA. RESULTS: A total of 464 patients were registered between January 2008 and December 2009, and 444 patients (283 men, mean age: 68.5 years) were included in the analysis. Thirteen patients (2.9%) presented with TMB. Patients with TMB were less likely to arrive at the specialized stroke center quickly than those without TMB (P = .013). Stenotic lesions in the extracranial internal carotid artery were more common in patients with TMB (33.3% versus 9.1%, P = .022). CONCLUSIONS: TMB was not common in our TIA inpatients. This study suggests that patients with TMB should immediately undergo a diagnostic workup, including brain and vessel imaging, and cardiac evaluation, as is performed in patients with other cerebral TIA symptoms. A larger, prospective cohort is needed to confirm the risks and outcomes of patients with TMB in the Japanese population.
BACKGROUND: Transient monocular blindness (TMB) is associated with a transient ischemic attack (TIA). The purpose of this study was to investigate the features of TMB in the Japanese population using data from a multicenter retrospective study of TIA. METHODS: The subjects were consecutive TIA patients admitted to 13 stroke centers within 7 days after symptom onset. We compared clinical characteristics of patients with TMB and those without TMB who had other symptoms of cerebral TIA. RESULTS: A total of 464 patients were registered between January 2008 and December 2009, and 444 patients (283 men, mean age: 68.5 years) were included in the analysis. Thirteen patients (2.9%) presented with TMB. Patients with TMB were less likely to arrive at the specialized stroke center quickly than those without TMB (P = .013). Stenotic lesions in the extracranial internal carotid artery were more common in patients with TMB (33.3% versus 9.1%, P = .022). CONCLUSIONS: TMB was not common in our TIA inpatients. This study suggests that patients with TMB should immediately undergo a diagnostic workup, including brain and vessel imaging, and cardiac evaluation, as is performed in patients with other cerebral TIA symptoms. A larger, prospective cohort is needed to confirm the risks and outcomes of patients with TMB in the Japanese population.