OBJECTIVE: To evaluate behavioral changes and brain-derived neurotrophic factor (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days. METHOD: Behavioral evaluation was undertaken at 1 and 6 hours after the last injection. RESULTS: We observed hyperlocomotion 1 hour after the last injection and a decrease in locomotion after 6 hours. Immobility time was decreased and climbing time was increased 6 hours after the last injection. BDNF levels were decreased in the prefrontal cortex and amygdala when rats were killed 6 hours after the last injection, compared to the saline group and to rats killed 1 hour after the last injection. BDNF levels in the striatum were decreased in rats killed 6 hours after the last ketamine injection, and BDNF levels in the hippocampus were decreased in the groups that were killed 1 and 6 hours after the last injection. CONCLUSION: These results suggest that the effects of ketamine on behavior and BDNF levels are related to the time at which they were evaluated after administration of the drug.
OBJECTIVE: To evaluate behavioral changes and brain-derived neurotrophic factor (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days. METHOD: Behavioral evaluation was undertaken at 1 and 6 hours after the last injection. RESULTS: We observed hyperlocomotion 1 hour after the last injection and a decrease in locomotion after 6 hours. Immobility time was decreased and climbing time was increased 6 hours after the last injection. BDNF levels were decreased in the prefrontal cortex and amygdala when rats were killed 6 hours after the last injection, compared to the saline group and to rats killed 1 hour after the last injection. BDNF levels in the striatum were decreased in rats killed 6 hours after the last ketamine injection, and BDNF levels in the hippocampus were decreased in the groups that were killed 1 and 6 hours after the last injection. CONCLUSION: These results suggest that the effects of ketamine on behavior and BDNF levels are related to the time at which they were evaluated after administration of the drug.
Authors: Linda Nguyen; Brandon P Lucke-Wold; Aric F Logsdon; Anna L Scandinaro; Jason D Huber; Rae R Matsumoto Journal: Neuroreport Date: 2016-09-28 Impact factor: 1.837
Authors: Fernanda Yvelize Ramos de Araújo; Adriano José Maia Chaves Filho; Adriana Mary Nunes; Gersilene Valente de Oliveira; Patrícia Xavier Lima Gomes; Germana Silva Vasconcelos; Jaqueline Carletti; Manoel Odorico de Moraes; Maria Elisabete de Moraes; Silvânia Maria Mendes Vasconcelos; Francisca Cléa Florenço de Sousa; David Freitas de Lucena; Danielle S Macedo Journal: Metab Brain Dis Date: 2021-09-07 Impact factor: 3.584
Authors: Matjaž Stenovec; Eva Lasič; Mićo Božić; Saša Trkov Bobnar; Randy F Stout; Vladimir Grubišić; Vladimir Parpura; Robert Zorec Journal: Mol Neurobiol Date: 2015-12-12 Impact factor: 5.590