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Literature DB >> 24141088

A path forward for the chlamydial virulence factor CPAF.

Turner A Conrad¹, Zhangsheng Yang, David Ojcius, Guangming Zhong.

Abstract

CPAF is a conserved and secreted protease from obligate intracellular bacteria of the order Chlamydiales. Recently, it was demonstrated that most of its host targets are an artifact of inaccurate methods. This review aims to summarize key features of CPAF and propose new approaches for evaluating its role in chlamydial pathogenesis.

Entities: CellLine Chemical Disease Mutation Species

Keywords: CPAF; Chlamydial virulence factors and pathogenesis; Substrates

Mesh：

Substances：

Year: 2013 PMID： 24141088 PMCID： PMC4320975 DOI： 10.1016/j.micinf.2013.09.008

Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700

61 in total

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Authors: Xiaofeng Bao; Bryce E Nickels; Huizhou Fan
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Authors: Ashlesh K Murthy; M Neal Guentzel; Guangming Zhong; Bernard P Arulanandam
Journal: J Reprod Immunol Date: 2009-10-23 Impact factor: 4.054

7. Intramolecular dimerization is required for the chlamydia-secreted protease CPAF to degrade host transcriptional factors.

Authors: Feng Dong; Jyotika Sharma; Yanming Xiao; Youmin Zhong; Guangming Zhong
Journal: Infect Immun Date: 2004-07 Impact factor: 3.441

A path forward for the chlamydial virulence factor CPAF.

1. The chlamydial plasmid-encoded protein pgp3 is secreted into the cytosol of Chlamydia-infected cells.

2. Generation of targeted Chlamydia trachomatis null mutants.

3. Chlamydia trachomatis protein GrgA activates transcription by contacting the nonconserved region of σ66.

4. Sexually transmitted diseases and tubal pregnancy.

Review 5. Chlamydia pneumoniae (TWAR).

Review 6. Chlamydial protease-like activity factor--insights into immunity and vaccine development.

7. Intramolecular dimerization is required for the chlamydia-secreted protease CPAF to degrade host transcriptional factors.

8. Cleavage-dependent activation of a chlamydia-secreted protease.

9. The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol.

10. Chlamydia trachomatis GlgA is secreted into host cell cytoplasm.

1. Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37.

Review 2. Chlamydia cell biology and pathogenesis.

3. The Chlamydia protease CPAF: caution, precautions and function.

4. Structural basis of the proteolytic and chaperone activity of Chlamydia trachomatis CT441.

5. Characterization of CPAF critical residues and secretion during Chlamydia trachomatis infection.

6. Analysis of CPAF mutants: new functions, new questions (the ins and outs of a chlamydial protease).

7. Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches.

8. The Chlamydia-Secreted Protease CPAF Promotes Chlamydial Survival in the Mouse Lower Genital Tract.

9. Chlamydial protease-like activity factor mediated protection against C. trachomatis in guinea pigs.

10. Detection of Chlamydia Developmental Forms and Secreted Effectors by Expansion Microscopy.