Literature DB >> 24141087

Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte.

Paige Selvy Dunphy1, Tian Luo, Jere W McBride.   

Abstract

Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.
Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Effector; Ehrlichia; Human monocytotropic ehrlichiosis; Moonlighting protein; Nucleomodulin; Post translational modification; Tandem repeat protein; Type 1 secretion system; Zoonosis

Mesh：

Substances：

Year:  2013        PMID： 24141087      PMCID： PMC3886233          DOI： 10.1016/j.micinf.2013.09.011

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  63 in total

1.  The 120 kDa outer membrane protein of Ehrlichia chaffeensis: preferential expression on dense-core cells and gene expression in Escherichia coli associated with attachment and entry.

Authors:  V L Popov; X j Yu; D H Walker
Journal:  Microb Pathog       Date:  2000-02       Impact factor: 3.738

Review 2.  Human ehrlichioses.

Authors:  Juan P Olano; David H Walker
Journal:  Med Clin North Am       Date:  2002-03       Impact factor: 5.456

3.  Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells.

Authors:  Mingqun Lin; Michael X Zhu; Yasuko Rikihisa
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

4.  Kinetics of antibody response to Ehrlichia canis immunoreactive proteins.

Authors:  Jere W McBride; Richard E Corstvet; Steven D Gaunt; Charles Boudreaux; Thaya Guedry; David H Walker
Journal:  Infect Immun       Date:  2003-05       Impact factor: 3.441

5.  Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles.

Authors:  Weichao Bao; Yumi Kumagai; Hua Niu; Mamoru Yamaguchi; Koshiro Miura; Yasuko Rikihisa
Journal:  J Bacteriol       Date:  2008-10-24       Impact factor: 3.490

6.  Expression and porin activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis development.

Authors:  Yumi Kumagai; Haibin Huang; Yasuko Rikihisa
Journal:  J Bacteriol       Date:  2008-03-21       Impact factor: 3.490

7.  An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking.

Authors:  Abdul Wakeel; Jeeba A Kuriakose; Jere W McBride
Journal:  Infect Immun       Date:  2009-03-09       Impact factor: 3.441

8.  Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins.

Authors:  Haibin Huang; Mingqun Lin; Xueqi Wang; Takane Kikuchi; Heather Mottaz; Angela Norbeck; Yasuko Rikihisa
Journal:  Infect Immun       Date:  2008-05-19       Impact factor: 3.441

9.  Ehrlichia ewingii infection delays spontaneous neutrophil apoptosis through stabilization of mitochondria.

Authors:  Qingming Xiong; Weichao Bao; Yan Ge; Yasuko Rikihisa
Journal:  J Infect Dis       Date:  2008-04-15       Impact factor: 5.226

10.  Limited transcriptional responses of Rickettsia rickettsii exposed to environmental stimuli.

Authors:  Damon W Ellison; Tina R Clark; Daniel E Sturdevant; Kimmo Virtaneva; Ted Hackstadt
Journal:  PLoS One       Date:  2009-05-19       Impact factor: 3.240
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  17 in total

1.  Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival.

Authors:  Bing Zhu; Seema Das; Shubhajit Mitra; Tierra R Farris; Jere W McBride
Journal:  Infect Immun       Date:  2017-08-18       Impact factor: 3.441

Review 2.  Hacking the host: exploitation of macrophage polarization by intracellular bacterial pathogens.

Authors:  Joseph D Thiriot; Yazmin B Martinez-Martinez; Janice J Endsley; Alfredo G Torres
Journal:  Pathog Dis       Date:  2020-02-01       Impact factor: 3.166

3.  Ehrlichia chaffeensis Exploits Canonical and Noncanonical Host Wnt Signaling Pathways To Stimulate Phagocytosis and Promote Intracellular Survival.

Authors:  Tian Luo; Paige S Dunphy; Taslima T Lina; Jere W McBride
Journal:  Infect Immun       Date:  2015-12-28       Impact factor: 3.441

4.  Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.

Authors:  Paige Selvy Dunphy; Tian Luo; Jere W McBride
Journal:  Infect Immun       Date:  2014-07-21       Impact factor: 3.441

5.  Review: Protective Immunity and Immunopathology of Ehrlichiosis.

Authors:  Nahed Ismail; Aditya Sharma; Lynn Soong; David H Walker
Journal:  Zoonoses (Burlingt)       Date:  2022-07-05

6.  Ehrlichia chaffeensis TRP32 is a Nucleomodulin that Directly Regulates Expression of Host Genes Governing Differentiation and Proliferation.

Authors:  Tierra R Farris; Paige S Dunphy; Bing Zhu; Clayton E Kibler; Jere W McBride
Journal:  Infect Immun       Date:  2016-08-29       Impact factor: 3.441

7.  MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock.

Authors:  Muhamuda Kader; Mounia Alaoui-El-Azher; Jennie Vorhauer; Bhushan B Kode; Jakob Z Wells; Donna Stolz; George Michalopoulos; Alan Wells; Melanie Scott; Nahed Ismail
Journal:  PLoS Pathog       Date:  2017-10-19       Impact factor: 6.823

8.  Immunoreactive Protein Repertoires of Ehrlichia chaffeensis and E. canis Reveal the Dominance of Hypothetical Proteins and Conformation-Dependent Antibody Epitopes.

Authors:  Tian Luo; Jignesh G Patel; Xiaofeng Zhang; David H Walker; Jere W McBride
Journal:  Infect Immun       Date:  2021-08-02       Impact factor: 3.609

Review 9.  Effector bottleneck: microbial reprogramming of parasitized host cell transcription by epigenetic remodeling of chromatin structure.

Authors:  Sara H Sinclair; Kristen E Rennoll-Bankert; J S Dumler
Journal:  Front Genet       Date:  2014-08-14       Impact factor: 4.599

10.  Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain.

Authors:  Valerie J Klema; Krishna Mohan Sepuru; Nadia Füllbrunn; Tierra R Farris; Paige S Dunphy; Jere W McBride; Krishna Rajarathnam; Kyung H Choi
Journal:  PLoS One       Date:  2018-04-11       Impact factor: 3.240
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