Roya Kelishadi1, Shadi Salek2, Mehdi Salek2, Mahin Hashemipour2, Mahsa Movahedian3. 1. Pediatrics Department, Child Growth and Development Research Center and Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: kelishadi@med.mui.ac.ir. 2. Pediatrics Department, Child Growth and Development Research Center and Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 3. Department of English Linguistics, University of Isfahan, Isfahan, Iran.
Abstract
OBJECTIVE: This triple-masked controlled trial aimed to assess the effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in obese children and adolescents. METHODS: The study comprised 50 participants, aged 10 to 16 years, who were randomly assigned into two groups of equal number. In this 12-week trial, one group received oral vitamin D (300,000 IU) and the other group received placebo. Cardiometabolic risk factors, insulin resistance, and a continuous value of metabolic syndrome (cMetS) were determined. Statistical analysis was conducted after adjustment for covariate interactions. RESULTS: Overall, 21 patients in the vitamin D group and 22 in the placebo group completed the trial. No significant difference was observed in the baseline characteristics of the two groups. After the trial, in the vitamin D group, serum insulin and triglyceride concentrations, as well as HOM -IR and C-MetS decreased significantly, both when compared with the baseline and with the placebo group. No significant difference was observed when comparing total cholesterol, LDL-C, HDL-C, fasting blood glucose, and blood pressure. CONCLUSION: The present findings support the favorable effects of vitamin D supplementation on reducing insulin resistance and cardiometabolic risk factors in obese children.
RCT Entities:
OBJECTIVE: This triple-masked controlled trial aimed to assess the effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in obesechildren and adolescents. METHODS: The study comprised 50 participants, aged 10 to 16 years, who were randomly assigned into two groups of equal number. In this 12-week trial, one group received oral vitamin D (300,000 IU) and the other group received placebo. Cardiometabolic risk factors, insulin resistance, and a continuous value of metabolic syndrome (cMetS) were determined. Statistical analysis was conducted after adjustment for covariate interactions. RESULTS: Overall, 21 patients in the vitamin D group and 22 in the placebo group completed the trial. No significant difference was observed in the baseline characteristics of the two groups. After the trial, in the vitamin D group, serum insulin and triglyceride concentrations, as well as HOM -IR and C-MetS decreased significantly, both when compared with the baseline and with the placebo group. No significant difference was observed when comparing total cholesterol, LDL-C, HDL-C, fasting blood glucose, and blood pressure. CONCLUSION: The present findings support the favorable effects of vitamin D supplementation on reducing insulin resistance and cardiometabolic risk factors in obesechildren.
Keywords:
Children and adolescents; Crianças e adolescentes; Insulin resistance; Metabolic syndrome; Resistência à insulina; Síndrome metabólica; Vitamin D; Vitamina D
Authors: Giuseppe Saggese; Francesco Vierucci; Flavia Prodam; Fabio Cardinale; Irene Cetin; Elena Chiappini; Gian Luigi De' Angelis; Maddalena Massari; Emanuele Miraglia Del Giudice; Michele Miraglia Del Giudice; Diego Peroni; Luigi Terracciano; Rino Agostiniani; Domenico Careddu; Daniele Giovanni Ghiglioni; Gianni Bona; Giuseppe Di Mauro; Giovanni Corsello Journal: Ital J Pediatr Date: 2018-05-08 Impact factor: 2.638
Authors: Ashley J Ferira; Emma M Laing; Dorothy B Hausman; Daniel B Hall; George P McCabe; Berdine R Martin; Kathleen M Hill Gallant; Stuart J Warden; Connie M Weaver; Munro Peacock; Richard D Lewis Journal: J Clin Endocrinol Metab Date: 2016-02-17 Impact factor: 5.958
Authors: Katherine Tomaino; Karina M Romero; Colin L Robinson; Lauren M Baumann; Nadia N Hansel; Suzanne L Pollard; Robert H Gilman; Edward Mougey; John J Lima; William Checkley Journal: Am J Hypertens Date: 2015-01-19 Impact factor: 2.689
Authors: Dong Phil Choi; Sun Min Oh; Ju-Mi Lee; Hye Min Cho; Won Joon Lee; Bo-Mi Song; Yumie Rhee; Hyeon Chang Kim Journal: PLoS One Date: 2014-07-29 Impact factor: 3.240