Literature DB >> 2414035

Measurement of myelin basic protein by radioimmunoassay in closed head trauma, multiple sclerosis and other neurological diseases.

A Mukherjee, R F Vogt, D S Linthicum.   

Abstract

A double antibody sequential radioimmunoassay for human myelin basic protein (MBP) has been developed. The assay utilizes a rabbit antibody to human MBP and purified rabbit MBP as the radiolabelled antigen. This assay was used to analyze cerebrospinal fluid (CSF) from 22 patients with severe head injury, 61 other cases of various neurological disorders, and 106 normal controls. The results showed that closed head trauma caused moderate to severe elevations in CSF MBP, and elevated CSF MBP was detectable in several diseases which involve CNS myelin.

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Year:  1985        PMID： 2414035     DOI： 10.1016/s0009-9120(85)80037-0

Source DB:  PubMed          Journal:  Clin Biochem        ISSN： 0009-9120            Impact factor:   3.281


  3 in total

1.  The short-term effect of an immunosuppressive treatment on CSF myelin basic protein in chronic progressive multiple sclerosis.

Authors:  K J Lamers; B M Uitdehaag; O R Hommes; W Doesburg; R A Wevers; W J von Geel
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-10       Impact factor: 10.154

2.  Increased CSF concentrations of myelin basic protein after TBI in infants and children: absence of significant effect of therapeutic hypothermia.

Authors:  E Su; M J Bell; P M Kochanek; S R Wisniewski; H Bayir; R S B Clark; P D Adelson; E C Tyler-Kabara; K L Janesko-Feldman; R P Berger
Journal:  Neurocrit Care       Date:  2012-12       Impact factor: 3.210

Review 3.  Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research.

Authors:  Jonathan M Levine; Gwendolyn J Levine; Brian F Porter; Kimberly Topp; Linda J Noble-Haeusslein
Journal:  J Neurotrauma       Date:  2011-03-25       Impact factor: 5.269
  3 in total

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